Steroid Hormone Receptor Systems

ISBN-13: 9781475765915 / Angielski / Miękka / 2013 / 489 str.

W. W. Leavitt

Opis

The papers in this volume were presented at the Symposium on Steroid Hormone Receptor Systems held October 18-20, 1978, at the Worcester Foundation for Experimental Biology, Shrewsbury, Mass. The meeting was organized to review, discuss, and disseminate new knowledge about the regulation and function of the receptor proteins which mediate estrogen, progestin, glucocorticoid, and androgen action. The symposium brought together leading scientists whose interests span the spectrum of biological organization. On this occasion, Drs. Elwood V. Jensen and Etienne E. Baulieu were honored as recipients of the Tenth Annual Gregory Pincus l1emorial Award for their pioneering studies of steroid hormone receptors. The material covered in this book focuses on the molecular mechanisms which control receptor site availability and function. The topics discussed include recent work on receptor antibodies, antiestrogen action, receptor heterogeneity, nuclear binding and processing of receptor, receptor activation and inactivation mechan- isms, interactions between receptor systems, influence of biological rhythms, membrane binding sites, and the evolution of steroid-bind- ing proteins. Although studies on steroid receptors have led to the development of new approaches for cancer therapy and contraception, much remains to be discovered in this rapidly expanding field. Hope- fully, this book will provide added impetus to the quest for a full understanding of steroid receptor systems by drawing attention to the unresolved questions yet to be answered. Hhile the book is intended primarily for those interested in hormone action, it should be of value to a more general audience including cell, molecular, and developmental biologists.

Spis treści

The Immunoendocrinology of Estrophilin.- Nuclear Binding of the Estrogen Receptor: Heterogeneity of Sites and Uterotropic Response.- The Specific Binding of Estradiol to the Nuclear Matrix.- Heterogeneity of Nuclear Glucocorticoid Receptor Interactions.- Estrogen Control of Progesterone Receptor Induction in Human Breast Cancer: Role of Nuclear Estrogen Receptor.- Estrogen and Antiestrogen Action: Studies in Reproductive Target Tissues and Tumors.- Inhibition of Cell Division and Stimulation of Progesterone Receptor Synthesis in Rat Oestrogen Target Tissues by Non-Steroidal Antioestrogens.- Steroid Hormone Regulation of Uterine Peroxidase Activity.- Progesterone Suppression of the Estradiol Receptor in the Reproductive Tract of Macaques, Cats, and Hamsters.- Regulation and Function of Estrogen and Progesterone Receptor Systems.- Effects of Progestins on the Progesterone Receptor in Guinea Pig Uterus.- The Use of Medroxyprogesterone Acetate to Study Progestin Receptors in Immature, Pregnant, and Adult Rabbit Uterus.- Circannual Rhythms in Progesterone Receptor Levels and Functions.- In vivo Metabolism and Binding of 6?-Methyl-progesterone; A Progestin with Anti-Androgenic and Synandrogenic Activities.- Factors Regulating the Androgenic Action of Progestins in Mouse Kidney.- The Role of Ligand-Binding as a Determinant of the Structure and Activation of the Estrogen Receptor.- Structural Relationships Between the Chick Oviduct Progesterone Receptor A and B Proteins.- Characterization of the Avian Progesterone Receptor through the Use of Inhibitors.- Glucocorticoid Receptor Inactivation and Activation by Phosphorylation Mechanisms.- Glucocorticoid Receptor Cleavage by Leupeptin-Sensitive Enzymes in Rat Kidney Cytosol.- Aspects of Steroid Hormone Target-Cell Interactions.- Studies on the Mechanism of Estradiol Uptake by Rat Uterine Cells and on Estradiol Binding to Uterine Plasma Membranes.- Heterogeneity of AtT-20 Cell Glucocorticoid Binding Sites: Evidence for a Membrane Receptor.- Sex Steroid Binding Proteins in Non-Mammalian Vertebrates.- The Ovalbumin Gene: Transcriptional Regulation by Estrogen.