Stem Cells and CNS Development

ISBN-13: 9780896038868 / Angielski / Twarda / 2001 / 370 str.

Mahendra S. Rao

Opis

Stem Cells and CNS Development critically reviews recent findings on stem cells, their involvement in neurogenesis and gliogenesis, and the therapeutic implications of these findings. It defines by consensus the classes of stem cells in the nervous system, compares their similarities and differences, discusses the gains made in identifying human homologs of neural stem cells, and describes how these cells are beginning to be used
for therapeutic purposes. Comprehensive and cutting-edge, this book provides all developmental scientists and neurobiologists not only an authoritative account of the current results in neural stem cell research, but also an incisive review of the rapidly emerging therapeutic uses of stem cells.

Recenzje

"This is a surprisingly readable book. It is also very informative. Any interested clinician that wants a broad overview of the field should consult this text; so should anyone considering research in this exciting and rapidly developing field." -British Journal of Neurosurgery

Spis treści

Defining Neural Stem Cells and Their Role in Normal Development of the Nervous System Sally Temple Multipotent Stem Cells in the Embryonic Nervous System John A. Kessler, Mark F. Mehler, and Peter C. Mabie Multipotent Stem Cells in the Adult Central Nervous System Luca Bonfanti, Angela Gritti, Rossella Galli, and Angelo L. Vescovi Glial Characteristics of Adult Subventricular Zone Stem Cells Daniel A. Lim and Arturo Alvarez-Buylla Neuronal Restricted Precursors Giri Venkatraman and Marla B. Luskin Glial Restricted Precursors Mark Noble and Margot Mayer-Pröschel PNS Precursor Cells Tanya A. Moreno and Marianne Bronner-Fraser Neural Progenitor Cells of the Adult Human Brain Steven A. Goldman ES Cells and Neurogenesis John W. McDonald Mobilizing Endogenous Stem Cells Theo D. Palmer, Sophia Colamarino, and Fred H. Gage Transplant Therapy Barbara A. Tate, Kate A. Bower, and Evan Y. Snyder Drug Discovery and Gene Discovery Alexander Kamb and Mahendra S. Rao Appendix A: Neural Stem Cell Companies Appendix B: Stem Cells and Transplants Appendix C: Patents and Stem Cells Appendix D: Stem Cells and US Federal Guidelines About the Authors

Blurb

Stem cells were recently cited by Science magazine as the scientific breakthrough of the year because of their potential to revolutionize our understanding of the complexities of biological development. In Stem Cells and CNS Development, world renowned authorities in neural stem biology critically review the rapidly emerging findings on this critical class of stem cells, their involvement in neurogenesis and gliogenesis, and the therapeutic implications of these findings. The authors define by consensus the classes of stem cells in the nervous system, compare their similarities and differences, discuss the gains made in identifying human homologs of neural stem cells, and describe how these cells are beginning to be used for therapeutic purposes. Their examination includes all the major issues in stem cell biology, save apoptosis and cell cycle regulators.
Comprehensive and cutting-edge, Stem Cells and CNS Development provides all developmental scientists and neurobiologists not only an authoritative account of the current results in neural stem cell research, but also an incisive review of the rapidly emerging therapeutic uses of stem cells.