Stem Cells Handbook

ISBN-13: 9781461476955 / Angielski / Miękka / 2013 / 534 str.

Stewart Sell

Opis

This book discusses critical areas of progress in stem cell research, including the most recent research and applications of pluripotent embryonic cells, induced pluripotent cells, oligopotent tissue stem cells and cancer stem cells. The text covers basic knowledge of stem cell biology, stem cell ethics, development of techniques for applying stem cell therapy, the technology of obtaining appropriate cells for transplantation as well as the role of stem cells in cancer and how therapy may be directed to cancer stem cells. This new volume is essential reading for all scientists currently in the field or allied research areas, and those for those graduate students who envision a career in stem cells.

Spis treści

Introduction to Stem Cells.- Contemporary Ethical Issues in Stem Cell Research.- Stem Cells from Early Mammalian Embryos.- Quantitative Approaches to Model Pluripotency and Differentiation in Stem Cells.- Growth Dynamics of Fetal Human Neural Stem Cells.- Immunobiology of Embryonic and Induced Pluripotent Stem Cell Transplantation.- Urodele Limb Regeneration: Mechanisms of Blastema Formation and Growth.- Mechanism of miR302-Mediated iPS Cell Generation.- Bioreactor Expansion of Pluripotent Stem Cells.- Generation of Hepatocyte-like Cells from Human Pluripotent Stem Cells.- Neural Differentiation from Pluripotent Stem Cells.- Generation of Anterior Foregut Derivatives from Pluripotent Stem Cells.- Commercial Opportunities for Induced Pluripotent Stem Cells.- Spermatogonial Stem Cells in Adult Mice and Men.- Characterization of the Hematopoietic Stem Cell Niche: Cellular and Molecular Analysis.- Glandular Stem Cells (GSCs): Stem Cells in Glandular Organs.- Human Mammary Epithelial Stem/Progenitor Cells.- Mammary Epithelial Stem Cells.- Gastric Stem Cell Biology: Proliferation Kinetics, Differentiation Hierarchies and Role in Carcinogenesis.- Progenitors of Islet Cells.- Stem Cell Populations Giving Rise to Liver, Biliary Tree and Pancreas.- Liver Regeneration in Health and Disease.- Human Induced Pluripotent Stem Cells, Embryonic Stem Cells and their Cardiomyocyte Derivatives: An Overview.- Potential of Glial Cells.- Stem Cells and Aging.- Translating Stem Cell Discoveries.- Mesenchymal Stem Cell Transplantation: From Tissue Regeneration to Immune Modulation.- Stem Cells and Tissue Engineering in Burns and Wounds.- Derivation of Retinal Pigmented Epithelial Cells for the Treatment of Ocular Disease.- Stem Cells and Diabetes.- Cancer is a Problem of Developmental Biology: Maturation Arrest and the Hierarchical Model of the Origin of Cancer from Stem Cells.- Targeting the Stem Cell Plasticity of Tumor Cells.- Molecular Evolution of Leukemia Stem Cells.- Rodent Models for Assessing the Role of Stem Cells in Liver Development, Regeneration and Carcinogenesis.- Breast Cancer Stem Cells: From Theory to Therapy.- Nephroblastoma/Wilms Tumor: A Corrupted Cap Stem Cell Caricature.

O autorze

Dr. Sell is a board certified pathologist and immunologist. He began research in 1957 while a medical student at the University of Pittsburgh, in the Department of Pathology, under Frank J. Dixon. After a pathology residency at Massachusetts Hospital, and post doctoral fellowships at NIH and Birmingham England he returned to the University of Pittsburgh for 5 years before moving to the University of California at San Diego. After 12 years at UCSD, Dr. Sell took the position as Chair of Pathology and Laboratory Medicine at the University of Texas (UT) at Houston before moving to Albany Medical College. As of February 2003 he has been a senior scientist at Wadsworth Center, a Professor at University at Albany School of Public Health and an Adjunct Professor at Albany College of Pharmacy. Dr. Sell received the Rudolph L. K. Virchow Award of the Italian Medical Magazine LeadershipMedica.com for his concept of cancer stem cells; he was named Legacy Laureate of the University of Pittsburgh for his work on alpha-fetoprotein as a marker for liver cancer; and in 2007 received the Abbott Award of the International Society for Oncodevelopmental Biology and Medicine for recognizing the role of stem cells in carcinogenesis. He has published over 400 papers and 12 books, including 6 editions of Immunology, Immunopathology and Immunity. His paper with Barry Pierce (Lab. Invest. 70:6-21, 1994.) was selected as an AACR scientific landmark.

Blurb

Stem Cells Handbook, second edition, emphasizes the advances in understanding and working with embryonic and fetal stem cells as well as induced pluripotent stem cells that show the most promise for clinical use. This new edition has been completely rewritten and updated to reflect the significant advances made in this field since publication of the first edition in 2004.

The thirty-six chapters in this book – all written by recognized experts in Stem Cell research – reflect the tremendous progress in the understanding of stem cell biology and the appreciation of the potential for using stem cells for therapy of cancer, aging, injury and congenital diseases. Arguably the biggest advances have been made in obtaining different populations of stem cells, inducing mature cells to act like stem cells, and the ever-critical issue of how to get these stem cells to expand and differentiate into the tissue precursor cells that then can be used to replace lost of damaged tissues.

No less exciting are the recent advances in understanding how stem cells function to maintain tissue integrity and how to use this knowledge to prevent developmental abnormalities. Other key topics discussed include: properties of tissue stem cells , transplantation of stem cells, the stem cell as a target for cancer treatment and prevention.