Stem Cells: Biology and Application

ISBN-13: 9780367481728 / Angielski / Twarda / 2020 / 464 str.

Mary Clarke; Jonathan Frampton

Opis

This textbook presents the basic concepts underlying the fast-moving science of stem cell biology. Stem Cells provides a comprehensive understanding of these unique cells, highlighting key areas of research, associated controversies, case studies, technologies, and pioneers in the field. 

Spis treści

AN INTRODUCTION TO STEM CELLS. The essential principles of stem cell science. Stem cell identification, isolation, and characterization. STEM CELL POTENCY AND CONTROL. Embryonic stem cells, cloning, and pluripotency. Controlling stem cells: Receipt and interpretation of external cues. Cell plasticity, reprogramming, and induced pluripotent stem cells. The stem cell niche. STEM CELLS ACROSS THE ANIMAL AND PLANT KINGDOMS. Regeneration in animals: The evolution of stem cells. Plant stem cells. STEM CELLS IN SPECIALIZED ADULT ANIMAL TISSUES. Hematopoietic stem cells. Musculo-skeletal and dental stem cells in mammals. Stem cells in endoderm-derived organs. Stem cells underpinning the generation of germ cells. Stem cells in the cardiovascular system. Stem cells in the nervous and sensory systems. Stem cells in the skin, its appendages, and other epithelial tissues. Atypical stem cells that enable and modulate immune system function. BIOMEDICAL AND ECONOMIC APPLICATIONS OF STEM CELLS. Stem cells in biomedicine: Disease modeling and tissue repair. Stem cells in biomedicine: Stem cells in aging and cancer. Stem cell applications in domesticated and wild animals and in horticulture. Stem cells and society: A philosophical, ethical, and economical view.

O autorze

Prof Jon Frampton and Dr Mary Clarke are stem cell biologists in the Institute of Cancer and Genomic Sciences at the University of Birmingham. Their main research involves hematopoietic stem cells, trying to understand how their normal behaviour is affected by disease and aging.