Stem Cell Research and Therapeutics

ISBN-13: 9781402085017 / Angielski / Twarda / 2008 / 326 str.

Yanhong Shi; Dennis O. Clegg

Opis

This book is an updated reference for one of the most exciting field of biomedical researches- Stem Cell Research and its therapeutic applications. Stem cell research holds great promise for the treatment of many human diseases that currently lack effective therapies. The set of chapters in this book provide insights into both basic stem cell biology and clinical applications of stem cell-based cell replacement therapies for a variety of human diseases, including cardiovascular diseases, neurological disorders, and li ver degeneration. It also covers novel technologies for the culture and differentiation of both human embryonic stem cells and adult tissue stem cells. This book summarizes our current state of knowledge in stem cell research and integrates basic stem cell biology with regenerative medicine in an overall context. It is an essential reference for students, postdoctoral fellows, academic and industrial scientists, and clinicians. v Acknowledgements The editors would like to thank Ms. Jill Brantley, Rose Chavarin, Alina Haas, and Emily Sun for their administrative assistance and proof-reading of this book. We would also like to thank all the authors for their contributions. vii The editors wish to dedicate this book to our mentors Ron Evans, Fred Gage, and, in memory of Daniel E. Koshland, Jr. Contents Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Acknowledgements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi 1 Retinal Pigment Epithelial Cells: Development In Vivo and Derivation from Human Embryonic Stem Cells In Vitro for Treatment of Age-Related Macular Degeneration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Dennis O. Clegg, David Buchholz, Sherry Hikita, Teisha Rowland, Qirui Hu, and Lincoln V.

Spis treści

1. Differentiation of retinal pigment epithelium from human embyronic stem cells: Lessons from in vivo Dennis Clegg, David Buchholz, Sherry Hikita, Teisha Rowland, Qirui Hu and Lincoln V. Johnson 2. Retinal Progenitor Cells Henry Klassen 3. Regulation of endogenous neural stem cells in sensory epithelia by TGFb and their antagonists. J. A. Hamilton, C. L. Beites, K. K. Gokoffski, P. L. W. Hollenbeck, S. Kawauchi, R. Santos, A. Bonnin, H. H. Wu, J. Kim, and A, Calof 4. Epigenetic control of neural stem cell self-renewal and specification GuoQiang Sun, Chunnian Zhao and Yanhong Shi 5. Neural stem cells and neurogenic niche Xuekun Li, Basam Z. Barkho and Xinyu Zhao 6. Progressing Neural Stem Cell Lines to the Clinic Kenneth Pollock and John Sinden 7. Human Neural Stem Cells for Biopharmaceutical Applications Lilian Hook, Norma Fulton, Gregor Russell, and Timothy Allsopp 8. Micro RNA profiling of embryonic and adult stem cell populations Loyal A. Goff, Uma Lakshmipathy, and Ronald P. Hart 9. Optimized Growth of Human Embryonic Stem Cells Matthew A. Singer, Jacqui Johnson, Paul Bello, Robert Kovelman, Michelle Greene 10. Potential of Stem Cells in Liver Regeneration Madhava Pai, Natasa Levicar, and Nagy A. Habib 11. Transplantation therapy for myocardial repair: current status and problems to be solved Wangde Dai and Robert Kloner 12. Clinical cardiac cell therapy Federico Benetti, Luis Geffner, Daniel Brusich, Agustin Fronzutti, Roberto Paganini, Juan Paganini and Amit Patel 13. High throughput technologies for directed differentiation of stem cells Yen Choo-Plasticell Limited 14. Adult Stem Cell Therapies for Tissue Regeneration: Ex vivo Expansion in an Automated System Kristin L. Goltry, Douglas Smith, James Dennis, Jon Rowley and Ronnda Bartel 15. Multipotency of hair follicle stem cells to produce neurons and other cell types for regenerative medicine Robert Hoffman

Blurb

This book is an updated reference for one of the most exciting fields of biomedical research- Stem Cell Research and its therapeutic applications. Stem cell research holds great promise for the treatment of many human diseases that currently lack effective therapies. The set of chapters in this book provide insights into both basic stem cell biology and clinical applications of stem cell-based cell replacement therapies for a variety of human diseases, including cardiovascular diseases, neurological disorders, and liver degeneration. It also covers novel technologies for the culture and differentiation of both human embryonic stem cells and adult tissue stem cells. This book summarizes our current state of knowledge in stem cell research and integrates basic stem cell biology with regenerative medicine in an overall context. It is an essential reference for students, research fellows, academic and industrial scientists, and clinicians.