Stem Cell Biology in Health and Disease

ISBN-13: 9789048130399 / Angielski / Twarda / 2009 / 440 str.

Thomas Dittmar; Kurt S. Zanker

Opis

Stem Cell Biology in Health and Disease presents an up-to-date overview about the dual role of stem cells in health and disease. The Editors have drawn together an international team of experts providing chapters which, in this fully-illustrated volume, discuss: - the controversial debate on the great expectations concerning stem cell based regeneration therapies raised by the pluripotency of various stem cells.
- the advantages and concerns about embryonic stem cells (ES cells), induced pluripotent stem cells (iPS cells) and adult stem cells, such as bone marrow-derived stem cells (BMDCs).
- the type of stem cells, which has become of interest in the past decade, namely so-called cancer stem cells (CSCs). CSCs are now in the focus of cancer research since the eradication of tumour initiating cells would raise the changes of definitely cure cancer. Professor Dittmar and Professor Zanker have edited a must-read book for researchers and professionals working in the field of regenerative medicine and/or cancer."

Recenzje

Aus den Rezensionen: "Ein Überblick zu Stammzellen in ihren verschiedenen Rollen bei Regeneration und Krebs? Ambitioniert. ... Das liegt einerseits am medium Buch. Ästhetisch ansprechend, nur dauert es eine Weile, bis es zusammengestellt und gedruckt ist. ... Viele wissenschaftliche Erkenntnisse sind beeindruckend, wenn sie zum ersten Mal geäußert werden ... Im einleitenden geschichtlichen Überblick stammen die aktuellsten Quellenangaben aus dem Jahr 2008. ... Als Aufsatzsammlung von Wissenschaftlern für Wissenschaftler will das Buch wiederum zu grundsätzlich und umfassend sein. ... Ein aktuelles und spannendes Thema ..." (in: Transkript, March/2010, Issue 3, S. 67)

Spis treści

1) Introduction; T. Dittmar, K.S. Zänker Bone marrow-derived stem cells 2) Hematopoietic stem and progenitor cells in clinical use – transplantation and mobilization; M. Punzel 3) Ex-vivo Expansion of HSPCs; Y. Wei 4) Modulation of hematopoietic stem/progenitor migration; T. Dittmar 5) Properties of mesenchymal stem cells to consider for cancer cell therapy; J. Stagg Embryonic stem cells 6) Alternative embryonic stem cell sources; T. Saric, J. Hescheler 7) Cell therapy in Parkinson’s Disease; R. Laguna Goya, R. A. Barker 8) Transplantation of stem cells and their derivatives in the treatment of multiple sclerosis; E. Larsen, I. Duncan Cancer Stem Cells 9) Cancer – A Stem Cell-based disease?; J. E. Trosko 10) Stem Cell Niche vs. Cancer Stem Cell Niche – Differences and Similarities; B. C. Baguley, G. J. Finlay 11) The chronically inflamed microenvironment and cancer stem cells; H. Li, C. Stoicov, X. Fan, J. Cerny, J.M. Houghton 12) Does the chronically inflamed periodontium harbour cancer stem cells?; W.-D. Grimm, W. H. Arnold, S. Becher, A. Dannan, G. Gassmann, S. Philippou, T. Dittmar, G. Varga 13) Cancer Stem Cells in the Haematopoietic System/ Haematopoietic Stem/ Progenitor Cell Disorders; M. Müschen 14) Cancer stem cells in solid tumors; M. G. Nafus, A. Y.Nikitin 15) 'One for all' or 'All for one'? – The necessity of cancer stem cell diversity in metastasis formation and cancer relapse; T. Dittmar, C. Nagler, S. Schwitalla, K. Krause, J. Seidel, G. Reith, B. Niggemann, K. S. Zänker 16) Elimination of Cancer Stem Cells; A. Sagrera, J. Pérez-Losada, M. Pérez-Caro, R. Jiménez, I. Sánchez-García, C. Cobaleda 17) Potential molecular therapeutic targets in cancer stem/progenitor cells: Are ATP-binding cassette membrane transporters appropriate targets to eliminate cancer-initiating cells?; M. Mimeault, S. K. Batra

O autorze

Dr. Thomas Dittmar promovierte bei Prof. Dr. Manfred Steiner am Lehrstuhl für Finanz- und Bankwirtschaft der Universität Augsburg. Heute ist er als Associate Consultant bei der Booz, Allen & Hamilton GmbH beschäftigt.

Blurb

Stem Cell Biology in Health and Disease presents an up-to-date overview about the dual role of stem cells in health and disease. The Editors have drawn together an international team of experts providing chapters which, in this fully-illustrated volume, discuss:

- the controversial debate on the great expectations concerning stem cell based regeneration therapies raised by the pluripotency of various stem cells.
- the advantages and concerns about embryonic stem cells (ES cells), induced pluripotent stem cells (iPS cells) and adult stem cells, such as bone marrow-derived stem cells (BMDCs).
- the type of stem cells, which has become of interest in the past decade, namely so-called cancer stem cells (CSCs). CSCs are now in the focus of cancer research since the eradication of tumour initiating cells would raise the changes of definitely cure cancer.

Professor Dittmar and Professor Zänker have edited a must-read book for researchers and professionals working in the field of regenerative medicine and/or cancer.