Stem Cell Biology and Regenerative Medicine

ISBN-13: 9788770224031 / Angielski / Twarda / 2021 / 400 str.

Charles Durand; Pierre Charbord

Opis

The study of stem cell biology is under intensive investigation. This book will cover many topics in the field and is based on conferences given by recognized scientists involved in the international master course on stem cell biology at Sorbonne Université in Paris.

Spis treści

• Preface.
• 1) General concepts
• Stem cell concepts.
• Transcriptional regulation in stem cells.
• Repair of DNA double-strand breaks in adult stem cells.
• Haematopoietic stem cell niches in the bone marrow.
• Computational models of spatio-temporal stem cell organization.
• Omics investigations.
• 2) Pluripotent stem cells and regeneration
• The regulatory network of X chromosome inactivation.
• Pluripotent stem cells: a common evolutionary origin?
• Directed differentiation of human-induced pluripotent stem cells into hepatic cells: a transposable example of disease modeling and regenerative medicine applications.
• Hydra and stem cell evolution.
• Regeneration in amniotic vertebrates.
• Stem cells and regeneration in plants.
• 3) Adult stem cells
• Hematopoietic development in vertebrates.
• Developmental biology of hematopoietic stem cells: Non-cell autonomous mechanisms.
• Biology of hematopoietic stem cells in the adult.
• Epithelial stem cells in the skin.
• Mammary stem cells.
• Intestinal stem cells.
• Neural stem cells: adult and regenerative aspects.
• Bone marrow mesenchymal stem cells: from stemness to stromal property of hematopoietic support.
• Dental stem cells.
• Stem cells and retina: from regeneration to cell therapy.
• 4) Stem cell-related diseases and therapy using stem cells
• Leukemic stem cells.
• Glioblastoma stem cells.
• Cardiac tissue engineering for repair and regeneration of the heart.
• Stem cells for red blood cell production.
• Hematopoietic stem cells, gene and cell therapy.
• Prospectives for therapy with stem cells in skeletal muscular diseases.
• 5) Reglementary and philosophical aspects
• Legal framework for research on Human Embryonic Stem Cells in France and in Europe.
• Stem cell conceptual clarifications.
• Future outlook.

O autorze

Charles Durand, Pierre Charbord