Statistics for Biological Networks: How to Infer Networks from Data

ISBN-13: 9781439841471 / Angielski / Twarda / 2027 / 320 str.

Ernst Wit; Veronica Vinciotti; Vilda Purutcuoglu

Opis

An introduction to a new paradigm in social, technological, and scientific discourse, this book presents an overview of statistical methods for describing, modeling, and inferring biological networks using genomic and other types of data. It covers a large variety of modern statistical techniques, such as sparse graphical models, state space models, Boolean networks, and hidden Markov models. The authors address gene transcription data, microRNAs, ChIP-chip, and RNAi data. Along with end-of-chapter exercises, the text includes many real-world examples with implementations using a dedicated R package.

Spis treści

Introduction. From Clusters to Networks. Visualizing Networks. Inferring Network Topology. Network Identification. Static Network Models. Dynamic Network Models. Inference with Networks.

O autorze

An expert in the field of statistical bioinformatics, Ernst Wit is a professor of statistics and probability at the University of Groningen.

Veronica Vinciotti is a lecturer in statistics at Brunel University.

Vilda Purutcuoglu is an instructor in statistics at Middle East Technical University.