Statistical Testing Strategies in the Health Sciences

ISBN-13: 9781032402512 / Angielski / Miękka / 2022 / 688 str.

Albert Vexler;Alan D. Hutson;Xiwei Chen

Opis

Statistical Testing Strategies in the Health Sciences provides a compendium of statistical approaches for decision making, ranging from graphical methods and classical procedures through computationally intensive bootstrap strategies to advanced empirical likelihood techniques. It bridges the gap between theoretical statistical methods and practical procedures applied to the planning and analysis of health-related experiments.

The book is organized primarily based on the type of questions to be answered by inference procedures or according to the general type of mathematical derivation. It establishes the theoretical framework for each method, with a substantial amount of chapter notes included for additional reference. It then focuses on the practical application for each concept, providing real-world examples that can be easily implemented using corresponding statistical software code in R and SAS. The book also explains the basic elements and methods for constructing correct and powerful statistical decision-making processes to be adapted for complex statistical applications.

With techniques spanning robust statistical methods to more computationally intensive approaches, this book shows how to apply correct and efficient testing mechanisms to various problems encountered in medical and epidemiological studies, including clinical trials. Theoretical statisticians, medical researchers, and other practitioners in epidemiology and clinical research will appreciate the book’s novel theoretical and applied results. The book is also suitable for graduate students in biostatistics, epidemiology, health-related sciences, and areas pertaining to formal decision-making mechanisms.

This book provides a compendium of statistical approaches for decision making, ranging from graphical methods and classical procedures through computationally intensive bootstrap strategies to advanced empirical likelihood techniques. It bridges the gap between theoretical statistical methods and practical procedures applied to the planning and

Spis treści

Preliminaries: Welcome to the Statistical Inference Club: Some Basic Concepts in Experimental Decision Making. Statistical Software: R and SAS. Statistical Graphics. A Brief Ode to Parametric Likelihood. Tests on Means of Continuous Data. Empirical Likelihood. Bayes Factor–Based Test Statistics. The Fundamentals of Receiver Operating Characteristic Curve Analyses. Nonparametric Comparisons of Distributions. Dependence and Independence: Structures, Testing, and Measuring. Goodness-of-Fit Tests (Tests for Normality). Statistical Change-Point Analysis. A Brief Review of Sequential Testing Methods. A Brief Review of Multiple Testing Problems in Clinical Experiments. Some Statistical Procedures for Biomarker Measurements Subject to Instrumental Limitations. Calculating Critical Values and p-Values for Exact Tests. Bootstrap and Permutation Methods. References. Index.

O autorze

Albert Vexler is a tenured professor in the Department of Biostatistics at the State University of New York (SUNY) at Buffalo. Dr. Vexler is the associate editor of Biometrics and BMC Medical Research Methodology. He is the author and coauthor of various publications that contribute to the theoretical and applied aspects of statistics in medical research. Many of his papers and statistical software developments have appeared in statistical and biostatistical journals that have top-rated impact factors and are historically recognized as leading scientific journals. Dr. Vexler was awarded a National Institutes of Health grant to develop novel nonparametric data analysis and statistical methodology. His research interests include receiver operating characteristic curve analysis, measurement error, optimal designs, regression models, censored data, change point problems, sequential analysis, statistical epidemiology, Bayesian decision-making mechanisms, asymptotic methods of statistics, forecasting, sampling, optimal testing, nonparametric tests, empirical likelihoods, renewal theory, Tauberian theorems, time series, categorical analysis, multivariate analysis, multivariate testing of complex hypotheses, factor and principal component analysis, statistical biomarker evaluations, and best combinations of biomarkers.

Alan D. Hutson is the chair of biostatistics and bioinformatics at Roswell Park Cancer Institute. He is also the biostatistical, epidemiological, and research design director for SUNY’s National Institutes of Health–funded Clinical and Translational Research Award. Dr. Hutson is a fellow of the American Statistical Association, the associate editor of Communications in Statistics and the Sri Lankan Journal of Applied Statistics, and a New York State NYSTAR Distinguished Professor. He has written more than 200 peer-reviewed publications. Dr. Hutson’s methodological work focuses on nonparametric methods for biostatistical applications as they pertain to statistical functionals. He also has several years of experience in the design and analysis of clinical trials.

Xiwei Chen is a biostatistician at Johnson & Johnson Vision Care, Inc. She obtained her PhD in biostatistics from SUNY at Buffalo, where her advisor was Dr. Albert Vexler. Dr. Chen is the author or coauthor of more than 10 papers and several book chapters on biostatistical areas concerning statistical approaches related to disease diagnoses. She is also very active as a reviewer for statistical journals. Her research interests include empirical likelihood methods, the receiver operating characteristic curve methodology, and statistical diagnosis and its applications.