Statistical Modelling of Complex Medical Data

ISBN-13: 9780470023709 / Angielski / Twarda / 2004 / 496 str.

D'Agostino, Ralph B.

Opis

The Tutorials in Biostatistics have become a very popular feature of the prestigious Wiley journal, Statistics in Medicine (SIM). The introductory style and practical focus make them accessible to a wide audience including medical practitioners with limited statistical knowledge. This book represents the second of two volumes presenting the best tutorials published in SIM, focusing on statistical modeling of complex data. Topics include clustered data, hierarchical models, mixed models, genetic modeling, and meta-analysis. Each tutorial is focused on a medical problem, has been fully peer-reviewed and edited, and is authored by leading researchers in biostatistics. Many articles include an appendix on the latest developments since publication in the journal and additional references. This will appeal to statisticians working in medical research, as well as statistically-minded clinicians, biologists, epidemiologists and geneticists. It will also appeal to graduate students of biostatistics.

Recenzje

"The articles within the volume are self–contained, well written, and accessible to readers of widely ranging backgrounds. These volumes should be extremely valuable to practitioners " ( Journal of the American Statistical Association, December 2005)

"The biostatistical practitioners who use a broad range of statistical methods would definitely find beneficial and useful to have ′Tutorials in Biostatistics′ " (E–STREAMS, September 2005)

Spis treści

Preface.

Preface to Volume 2.

Part I: MODELLING A SINGLE DATA SET.

1.1 Clustered Data.

Extending the Simple Linear Regression Model to Account for Correlated Responses: An Introduction to Generalized Estimating Equations and Multi–Level Mixed Modelling (Paul Burton et al).

1.2 Hierarchical Modelling.

An Introduction to Hierarchical Linear Modelling (Lisa M. Sullivan et al).

Multilevel Modelling of Medical Data (Harvey Goldstein et al).

Hierarchical Linear Models for the Development of Growth Curves: An Example with Body Mass Index in Overweight /Obese Adults (Moonseong Heo et al).

1.3 Mixed Models.

Using the General Linear Mixed Model to Analyse Unbalanced Repeated Measures and Longitudinal Data (Avital Cnaan et al).

Modelling Covariance Structure in the Analysis of Repeated Measures Data (Ramon C. Littell et al).

Covariance Models for Nested Repeated Measures Data: Analysis of Ovarian Steroid Secretion Data (Taesung Park and Young Jack Lee).

1.4 Likelihood Modelling.

Likelihood Methods for Measuring Statistical Evidence (Jeffrey D. Blume).

Part II: MODELLING MULTIPLE DATA SETS: META–ANALYSIS.

Meta–Analysis: Formulating, Evaluating, Combining, and Reporting (Sharon–Lise T. Normand ).

Advanced Methods in Meta–Analysis: Multivariate Approach and Meta–Regression (Hans C. van Houwelingen et al).

Part III: MODELLING GENETIC DATA: STATISTICAL GENETICS.

Genetic Epidemiology: A Review of the Statistical Basis (E. A. Thompson).

Genetic Mapping of Complex Traits (Jane M. Olson et al).

A Statistical Perspective on Gene Expression Data Analysis (Jaya M. Satagopan and Katherine S. Panageas).

Part IV: DATA REDUCTION OF COMPLEX DATA SETS.

Statistical Approaches to Human Brain Mapping by Functional Magnetic Resonance Imaging (Nicholas Lange).

Disease Map Reconstruction (Andrew B. Lawson).

PART V: SIMPLIFIED PRESENTATION OF MULTIVARIATE DATA.

Presentation of Multivariate Data for Clinical Use: The Framingham Study Risk Score Functions (Lisa M. Sullivan et al).

O autorze

Ralph D′Agostino, Boston University, USA
One of the editors of Statistics in Medicine and editor of the Tutorials in Biostatistics series in the journal.

Blurb

The Tutorials in Biostatistics series has become a very popular feature of the journal, Statistics in Medicine. The tutorials are accessible, self–contained and of a uniformly high quality. This book is the second of two volumes presenting the best tutorials published in the journal, focusing on statistical modelling of complex medical data. Topics include clustered data, hierarchical models, mixed models, genetic modelling, and meta–analysis. Each tutorial has been fully peer–reviewed and edited, and authored by leading researchers in biostatistics.

• Presents a collection of tutorials in biostatistics, taken from the prestigious Wiley journal, Statistics in Medicine.
• Focuses on modelling of complex medical data, including clustered data, hierarchical models, mixed models, genetic modelling, and meta–analysis.
• Each tutorial has been fully peer reviewed and edited to ensure a high level of quality and to maintain the practical focus.
• Suitable for medical practitioners with a good understanding of statistics.
• Each tutorial has been authored by leading researchers in the field.

The Tutorials in Biostatistics volumes provide an authoritative and readable introduction to a wide range of topics suitable for statisticians working in medical research, as well as statistically–minded clinicians, biologists, epidemiologists, and geneticists. Graduate students of biostatistics will find they make excellent reference volumes to support their study.