Statistical Human Genetics: Methods and Protocols

ISBN-13: 9781617795541 / Angielski / Twarda / 2012 / 564 str.

Robert C. Elston;Jaya M. Satagopan;Shuying Sun

Opis

This Methods in Molecular Biology(t) volume describes statistical methods and computer programs in sufficient detail to make them more easily accessible to the beginner analyzing data. Examples demonstrate the running of programs and interpreting outputs.

Spis treści

1. Genetic terminology      

2. Identification of genotype errors

3. Detecting pedigree relationship errors       

4. Identifying cryptic relationships     

 

5. Estimating allele frequencies

6. Testing departure from Hardy-Weinberg proportions       

7. Estimating disequilibrium  coefficients                                          

 

8. Detecting familial aggregation

       

9. Estimating heritability from twin studies

   

10. Estimating heritability from nuclear family and pedigree data    

 

11. Correcting for ascertainment

12. Segregation analysis using the unified model     

 

13. Design considerations for genetic linkage and association studies         

 14. Model-based linkage analysis of a quantitative trait

                                                       

15. Model-based linkage analysis of a binary trait    

 

16. Model-free linkage analysis of a quantitative trait                                

         

17. Model-free linkage analysis of a binary trait        

 

18. Single marker association analysis for unrelated samples                     

19. Single marker family-based association analysis conditional on parental information   

                                                       

20. Single marker family-based association analysis not conditional on parental information         

 

 21. Allowing for population stratification in association analysis       

 

22. Haplotype inference    

23. Multi-SNP haplotype analysis methods for association analysis                                               

 24. Detecting rare variants

 25. The analysis of ethnic mixtures   

 26. Identifying gene interaction networks      

 27. Structural equation modeling      

 28. Genotype calling for the Affymetrix  platform                                          

29. Genotype calling for the Illumina platform

                                                       

30. Comparison of requirements and capabilities of major multipurpose software packages

                 

Blurb

Recent advances in genetics over the last quarter of a century, especially in molecular techniques, have dramatically reduced the cost of determining genetic markers and hence opened up a field of research that is increasingly helping to detect, prevent and/or cure many diseases that afflict humans. In Statistical Human Genetics: Methods and Protocols expert researchers in the field describe statistical methods and computer programs in the detail necessary to make them more easily accessible to the beginner analyzing data. Written in the highly successful Methods in Molecular Biology™ series format, with examples of running the programs and interpreting the program outputs, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results from human genetic data collected in the laboratory.

 

Thorough and as much as possible intuitive, Statistical Human Genetics: Methods and Protocols aids scientists in understanding the computer programs and analytical procedures they need to use.