Stat Inhibitors in Cancer

ISBN-13: 9783319429472 / Angielski / Twarda / 2016 / 195 str.

Alister C. Ward

Opis

This volume, which includes contributions from leading scientists and clinicians in the field, provides definitive, state-of-the-art information on STAT inhibitors in a biological and clinical context. It gives an overview of the biology of the STAT family of transcription factors and their role in cancer etiology. Additionally, it describes the raft of therapeutic approaches being used to inhibit STATs in the context of various cancers, covering the full spectrum of therapeutic approaches to inhibiting STATs, and presenting emerging data from clinical trials.

Spis treści

STATs in Health and Disease

Clifford Liongue, Rowena S. Lewis, Alister C. Ward*

STAT Proteins in Cancer

Rachel A. O’Keefe, Jennifer R. Grandis*

Translating STAT Inhibitors from the Lab to the Clinic

Suhu Lui, David Frank*

Historical Development of STAT3 Inhibitors and Early Results in Clinical Trials

Chao-Lan Yu, Richard Jove, James Turkson*

STAT3 Inhibitors in Cancer: A Comprehensive Update

Uddalak Bharadwaj, Moses M. Kasembeli, David J. Tweardy

Targeting Upstream Janus Kinases

Parisa Rasighaemi*, Alister C. Ward

Inhibitors of Upstream Inducers of STAT Activation

Janani Kumar*

O autorze

Alister C. Ward is Foundation Professor/Director of Pre-Clinical Studies, School of Medicine, Deakin University, Geelong, Australia.