Spherical Nucleic Acids: 4 Volumes

ISBN-13: 9789814800358 / Angielski / Twarda / 2020 / 1862 str.

Chad A. Mirkin

Opis

This book covers over two decades research on Spherical Nucleic Acids and their anisotropic analogues, including synthesis and fundamental properties, and applications in colloidal crystallization, adaptive matter, and nanomedicine, spanning extra- and intracellular diagnostics, gene regulation, and immunomodulation.

Spis treści

A DNA-based method for rationally assembling nanoparticles into macroscopic materials (Nature, 1996). Nanoparticle-Based Bio-Bar Codes for the Ultrasensitive Detection of Proteins (Science, 2003). Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation (Science, 2006).  Nano-flares: Probes for Transfection and mRNA Detection in Living Cells (JACS, 2007).  Cellular Response of Polyvalent Oligonucleotide-Gold Nanoparticle Conjugates (ACS Nano, 2010).  Nanoparticle Superlattice Engineering with DNA (Science, 2011). Nucleic Acid-Modified Nanostructures as Programmable Atom Equivalents: Forging a New ‘Table of Elements’ (Angew. Chem. Int. Ed., 2013).  DNA-mediated Engineering of Multicomponent Enzyme Crystals (PNAS, 2015).  Clathrate Colloidal Crystals (Science, 2017).

O autorze

Chad Mirkin is a chemist and nanoscientist known for his invention of SNAs and his contributions to nanolithography, supramolecular chemistry, and nanoparticle synthesis. He has authored >730 manuscripts and has >1100 patents to his name. He has also won >130 awards and has founded 7 companies. He is a former member of the President’s Council of Advisors on Science and Technology and a fellow of the American Academy of Arts and Sciences, the National Academy of Sciences, the National Academy of Medicine, and the National Academy of Engineering, USA.