Spatio-temporal properties of the mammalian DNA damage response » książka
Spatio-temporal properties of the mammalian DNA damage response
ISBN-13: 9783639138344 / Angielski / Miękka / 2009 / 172 str.
In this work, the author reviews the current status of our knowledge about the cell cycle and the DNA damage response, followed by presenting his own scientific contributions to these fields. The reader is introduced to the complex issues of how cells divide and deal with damage to their DNA, in general and easy-to-read terms. In addition, a dedicated section of the book describes microscopy based tools to study these phenomena, such as the application of DNA damage in defined areas of the nucleus by laser microirradiation and studies of protein mobility by photobleaching techniques. This more technical part of the book is supplemented with a detailed outline of mathematical frameworks to analyze the ensuing data and deduct biological meaningful knowledge from them. The authors own papers, which are sequentially presented and discussed in broader terms, were published in high impact factor journals such as Nature Cell Biology, Molecular Cell and Journal of Cell Biology.
In this work, the author reviews the current statusof our knowledge about the cell cycle and the DNA damage response,followed by presenting his own scientific contributions to thesefields. The reader is introduced to the complex issues of how cells divideand deal with damage to their DNA, in general and easy-to-readterms. In addition, a dedicated section of the book describes microscopybased tools to study these phenomena, such as the application of DNAdamage in defined areas of the nucleus by lasermicroirradiation and studies of protein mobility by photobleaching techniques. Thismore technical part of the book is supplemented with a detailedoutline of mathematical frameworks to analyze the ensuing dataand deduct biological meaningful knowledge from them. Theauthors own papers, which are sequentially presented and discussed inbroader terms, were published in high impact factor journals such asNature Cell Biology, Molecular Cell and Journal of Cell Biology.
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