Sourcebook of Models for Biomedical Research

ISBN-13: 9781588299338 / Angielski / Twarda / 2007 / 778 str.

P. Michael Conn

Opis

The collection of systems represented in Sourcebook of genomic programs, although this work is certainly well Models for Biomedical Research is an effort to re?ect the represented and indexed. diversity and utility of models that are used in biomedicine. Some models have been omitted due to page limitations That utility is based on the consideration that observations and we have encouraged the authors to use tables and made in particular organisms will provide insight into the ? gures to make comparisons of models so that observations workings of other, more complex, systems. Even the cell not available in primary publications can become useful to cycle in the simple yeast cell has similarities to that in the reader. humans and regulation with similar proteins occurs. We thank Richard Lansing and the staff at Humana for Some models have the advantage that the reproductive, guidance through the publication process. mitotic, development or aging cycles are rapid compared As this book was entering production, we learned of the with those in humans; others are utilized because individual loss of Tom Lanigan, Sr. Tom was a leader and innovator proteins may be studied in an advantageous way and that in scienti?c publishing and a good friend and colleague to have human homologs. Other organisms are facile to grow all in the exploratory enterprise. We dedicate this book to in laboratory settings or lend themselves to convenient analy- his memory. We will miss him greatly.

Recenzje

From the reviews:

"Conn, a distinguished scientist ... has created one of the most significant and comprehensive model reference tools in recent years. ... provides a system of relevancy that leads the serious student to adapt the model to their own different and perhaps unique research applications. The essays have a sufficient number of tables and overwhelmingly black-and-white figures and photographs to assist in comprehension. ... Very useful for libraries serving upper-division and graduate students in the life sciences." (John M. Robson, American Reference Books Annual, 2009)

"Sourcebook of Models for Biomedical Research is a collection of the various models developed over several decades in biomedicine. ... The chapters are presented clearly, easy to understand, and interesting to read. ... In summary, this book would be a great addition to the library of anyone who is interested in an overview of model development for biomedical research." (Dongwen Wang, The Quarterly Review of Biology, Vol. 85 (3), September, 2010)

Spis treści

Preface P. Michael Conn, PhD connm@ohsu.edu ONPRC/OHSU INTRODUCTORY 1 Animal models for human diseases: an overview Jann Hau JHAU@emed.ku.dk Panum Instituttet 2 Selection of biomedical animal models Michael S. Rand, DVM, DACLAM mrand@email.arizona.edu University of Arizona 3 Improved models for animal research Ernesto Bockamp, Dr.rer.nat. Leonid Eshkind, PhD Jan Hengstler, MD Rolf Sprengel, Dr. rer.nat. bockamp@mail.uni-mainz.de Johannes Gutenberg-Universität Mainz GENERAL CONSIDERATIONS 4 The ethical basis for animal use in research James V. Parker, PhD culligank@comcast.net 5 Bibliographic searching tools on disease models to locate alternatives for animals in research: A website companion Lynette A. Hart Mary W. Wood lahart@ucdavis.edu University of California - Davis 6 NIH policies on sharing of model organisms and related research resources Norka Ruiz Bravo, PhD Charlene Cho, PhD JP Kim, JD, MBA, MSc, MALS ruizbran@od.nih.gov NIH 7 Databases for biomedical animal resources Richard L. Crawford, DVM Tim Allen, MS AWKC@val.usda.gov UDSA 8 Psychological enrichment for animals in captivity Kristine Coleman colemank@ohsu.edu ONPRC/OHSU WELL-ESTABLISHED MODELS Yeast, Worms, Flies, Sea Animals and Birds 9 Integrated network modeling of molecular and genetic interactions Gregory W Carter, PhD Vesteinn Thorsson, PhD Timothy Galitski,PhD gcarter@systemsbiology.net Institute for Systems Biology 10 The sponge as a model of cellular recognition Xavier Fernandez-Busquets, PhD xfernandez_busquets@ub.edu University of Barcelona 11 Sea urchin embryo — a model system for analyzing a variety of cellular activities during early development Tetsuya Kominami Hiromi Takata tkom@sci.ehime-u.ac.jp Ehime University 12 C. elegans models of human neurodegenerative deseases: a powerful tool to identify molecular mechanisms and novel therapeutic targets Richard Nass, PhD Lihsia Chen richard.nass@vanderbilt.edu Vanderbilt University Medical Center 13 Zebrafish as a model for development Brian A Link, PhD Sean G. Megason, PhD blink@mail.mcw.edu Medical College of Wisconsin 14 Zebrafish as a model for studying adult effects of challenges to the embryonic nervous system Elwood A. Linney, PhD Nicole Marie Roy, PhD elwood.linney@duke.edu Duke University Medical Center 15 Modeling cognitive and neurodegenerative disorders in Drosophila melanogaster Minoru Saitoe Junjiro Horiuchi saitoe@tmin.ac.jp Tokyo Metropolitan Institute for Neuroscience (TMIN) 16 Biomedical research with honey bees Michelle M. Elekonich, PhD michelle.elekonich@unlv.edu University of Nevada Las Vegas 17 Establishing and maintaining a Xenopus laevis colony for research laboratories Michael Levin, PhD Punita Koustubhan Debra Sorocco mlevin@forsyth.org The Forsyth Center for Regenerative and Developmental Biology and Harvard School of Dental Medicine 18 The chicken as a model organism Janice M. Bahr,

O autorze

The collection of systems represented in this volume is an effort to reflect the diversity and utility of models that are used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This is a comprehensive and extensive collection of these important medical parallels. While the entire book is not devoted to the remarkable success of the genomic programs, this work is well represented and indexed. This volume will be an invaluable resource for pharmaceutical and academic researchers across a wide range of biological fields.

Blurb

The collection of systems represented in the Sourcebook of Models for Biomedical Research reflect the diversity and utility of models that are used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. Some models have the advantage that the reproductive, mitotic, development or aging cycles are rapid compared with those in humans; others are utilized because individual proteins may be studied in an advantageous way and have human homologs. Other organisms are facile to grow in laboratory settings, lend themselves to convenient analyses, have defined genomes or present especially good human models of human or animal disease. The Sourcebook of Models for Biomedical Research is a comprehensive and extensive collection of these important medical parallels. While the entire book is not devoted to the remarkable success of the genomic programs, this work is well represented and indexed within these pages. This volume will be an invaluable resource for pharmaceutical and academic researchers across a wide range of biological fields.