Sodium in Health and Disease

ISBN-13: 9780367388287 / Angielski / Miękka / 2019 / 480 str.

Michael Burnier

Opis

report on the latest developments in the field with new information in basic as well as in clinical sciences, Sodium in Health Diseases, covers both the physiology of sodium balance and how it relates to disease. Expertly written, its concise text examines ATPase, transport and receptor systems, and sodium balance as it relates to sex hormones, genes, and body fluid. This text will also examine disease based on animal models, genetic disorders, and the influence of sodium on pulse pressure, isolated systolic hypertension, and its blood pressure sensitivity.

Sodium in Health and Disease will

·                     cover the newest data on sodium transport by the epithelial sodium channel or the impact of renal structure proteins on sodium transport

·                     discuss the latest developments  in our understanding of the role of aldosterone and 11-beta-hydroxysteroid dehydrogenase in the regulation of sodium balance.

·                     present original observations on the role of salt in isolated systolic hypertension and in the development of arterial stiffness.

·                     give new data on renal sodium handling in women and in diabetes and the metabolic syndrome.

Important topics covered :

·                     the epithelial sodium channel

·                     renal structure proteins and sodium

Spis treści

Sodium-Potassium-ATPASE. The Epithelial Sodium Channel. The sodium-hydrogen exchange system. Renal Structure Proteins and Sodium Transport. Neural control of sodium balance. Aldosterone and Mineralcorticoid Receptors. β-hydroxysteroid dehydrogenase. Integrative Renal Regulation of Sodium Excretion. Animal models of abnormal sodium handling. Sodium and the Development of Hypertension Experimental Evidence. Salt and Hypertension:Epidemiological and Clinical Evidence for a Link. Influence of Sodium on Pulse Pressure and Systolic. Salt and blood pressure:the concept of salt sensitivity. Renal Sodium Handling in Women. Sodium Balance in Cirrhosis. Sodium Balance in Heart Failure. The kidney: a target organ of excessice dietary salt intake. Sodium balance in the metabolic syndrome and diabetes. Drug-induced alterations of sodium balance: the example of non-steroidal anti-inflammatory.agents. Position of diuretics in the management of hypertension. Sodium status and the response to blockade of the renin angiotensin system. Mineralocorticoid antagonists in heart failure and chronic renal failure.

O autorze

Michel Burnier