Smith and Williams' Introduction to the Principles of Drug Design and Action

ISBN-13: 9780415288774 / Angielski / Twarda / 2005 / 682 str.

John H. Smith; H. John Smith

Opis

As knowledge of biological systems has expanded and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionized the process of drug development for specific disease states.Smith and Williams' Introduction to the Principles of Drug Design and Action, 4th Edition provides a thorough introduction to the principles of rational drug design, including both novel and established approaches. The fourth edition of this popular textbook adopts a 'from the bench to the marketplace' approach, using real examples where possible. In addition to a comprehensive update of the previous edition, new advances in molecular techniques, biotechnological applications and computer-aided design have been added.

Recenzje

“This book consists of 17 chapters on a variety of topics related to drug design and action. … This book is intended as a possible text for undergraduate chemistry students interested in medicinal chemistry, or for graduate students as a means to learn the basics of medicinal chemistry. … classical approaches are described for drug design with the inclusion of the more recent context of the human genome project … In summary, some medicinal chemists in academia or the pharmaceutical industry may find this book instructive for certain classes of biomolecules or classical approaches to drug design. It should probably be included in most comprehensive library collections of medicinal chemistry texts and monographs.”
— Bruce L. Currie, Department of Pharmaceutical Sciences, Loma Linda University, California, in Journal of Medicinal Chemistry, , Vol. 50, No. 1, 2007
“The fourth edition of this book includes the latest information on topics such as gene therapy, computer-aided design, and molecular techniques including proteomics. … real-world examples that illustrate the principles of drug design … New features of this edition include: coverage of agonists and antagonists of neurotransmitters; the design of stable peptide-like drugs; the human genome and its impact on drug discovery and development; advances in therapy and pharmacokinetics.”
— In Anticancer Research, Vol. 26, 2006
Promo Copy

Spis treści

Contents
Processes of Drug Handling by the Body, M. Gumbleton
The Design of Drug Delivery Systems, I.W. Kellaway
Fundamental Pharmacokinetics, G. Taylor
Intermolecular Forces and Molecular Modeling, R.H. Davies
Drug Chirality and its Pharmacological Consequences, A.J. Hutt
Quantitative Structure–Activity Relationships (QSAR) in Drug Design, J.C. Dearden and M.T.D. Cronin
Prodrugs, A.W. Lloyd
From Program Sanction to Clinical Trials: A Partial View of the Quest for Arimidex, A Potent, Selective Inhibitor of Aromatase, P.N. Edwards
Design of Enzyme Inhibitors as Drugs, A. Patel, H.J. Smith, and T. Steinmetzer
Peptide Drug Design, D.J. Barlow
Combinatorial Chemistry: A Tool for Drug Discovery, B. Kellam
Recombinant DNA Technology: Monoclonal Antibodies, F.J. Rowell
The Human Genome and its Impact on Drug Discovery and Therapy, F.J. Rowell
The Chemotherapy of Cancer, D.E. Thurston
Neurotransmitters, Agonists, and Antagonists, R.D.E. Sewell, H.J. Smith, H. Stark, W. Schunack, and P.G. Strange
Design of Antibacterial, Antifungal, and Antiviral Agents, C. Simons and A.D. Russell
Pharmaceutical Applications of Bioinorganic Chemistry, D.M. Taylor and D.R. Williams Index

O autorze

H. John Smith, Hywel Williams