Small Molecule -- Protein Interactions

ISBN-13: 9783540439844 / Angielski / Twarda / 2003 / 228 str.

Waldmann, Herbert

Opis

Researchers describe ways of selecting promising new drug targets and developing small molecule inhibitors against them. This title surveys the approaches taken by different companies and institutions, providing the reader with assistance in selecting appropriate tools for their own work.

Spis treści

1 Drug Discovery Opportunities.- 2 Target Analysis: A Priori Assessment of Druggability.- 3 Drug Discovery at Signaling Interfaces.- 4 Chemical Genomics of Orphan Nuclear Receptors.- 5 High-Throughput X-Ray Techniques and Drug Discovery.- 6 NMR in Medicinal Chemistry.- 7 Creating Knowledge from High-Throughput Screening Data.- 8 From Structure to Recognition Principles: Mining in Crystal Data as a Prerequisite for Drug Design.- 9 Practical Database Screening with Docking Tools.- 10 De Novo Design Methods.- 11 From Protein Domains to Drug Candidates — Natural Products as Guiding Principles in Compound Library Design and Synthesis.- 12 Discovery of New MCRs, Chemical Evolution and Lead Optimization.- 13 The Impact of Combinatorial Chemistry on Drug Discovery.- Previous Volumes Published in This Series.