Sm-153 In Gastrointestinal Imaging : Extended use of Sm-153 in oral drug delivery and diagnostic imaging

ISBN-13: 9783659177507 / Angielski / Miękka / 2012 / 356 str.

Chai Hong Yeong; Alan Christopher Perkins

Opis

Samarium-153 (Sm-153) is a radionuclide that decays with physical half-life 46.3 hours through the emission of beta and gamma radiation. The beta energies are particularly suited for targeted radionuclide therapy, whereas the low energy gamma radiation is well suited for diagnostic imaging. In the last two decades, Sm-153 has been used as both a radiotracer for pharmacoscintigraphic studies and a therapeutic radionuclide for the treatment of bone metastasis. This book presents a study investigating the use of Sm-153 as a tracer for imaging in oral drug delivery and clinical diagnostics of gastrointestinal transit. The production, physical and imaging characteristics, in vitro experimental validation, clinical trial as well as radiation dosimetry of novel Sm-153 labelled formulations are explained in meticulous detail. Work from each of these chapters has been published in academic journals and international conferences and has received several awards. This book provides a complete compilation of the entire work.

O autorze

Dr Yeong is a Medical Physicist and she obtained her PhD with Distinction in 2012. Her research areas focus on the extended use of neutron-activated Sm-153 in diagnostic imaging, targeted radionuclide therapy as well as drug delivery. Her PhD work has won several awards including the Certificate of Merit in the European Radiology Congress, 2012.