Slow Virus Infections of the Central Nervous System: Investigational Approaches to Etiology and Pathogenesis of These Diseases

ISBN-13: 9781461298854 / Angielski / Miękka / 2013 / 258 str.

V. Ter Meulen;M. Katz

Opis

This book is a result of a Workshop held at the Institute of Virology of the Univer- sity of Wurzburg, Germany in March of 1975. The Workshop was organized to bring together investigators of slow virus infections and other scientists, who have not engaged in such research, but who were Ieaders in the field of biologic investi- gations. The conveners hoped that these latter would be more objective critics, who would express their views freely and who would offer recommendations for new directions and new approaches to the investigations of slow virus infections. These expectations were fulfilled as the organization of the Workshop permitted much free time for discussion as weil as time for directed critiques. This volume repre- sents an extensive summary of the proceedings and the discussions that followed. We believe it will be of interest to all investigators of slow virus infections and to the students of host-parasite relationships. Volker ter Meulen Michael Katz V Contents Preface v List of Gontributars xi PART I I UNCONVENTIONAL AGENTS Chapter 1 Scrapie: Pathogenesis in lnbred Mice: An Assessment of Host Control and Response lnvolving Many Strains of Agent 3 A. G. Dickinsan and H. Fraser Chapter 2 Kuru, Creutzfeldt-Jakob Disease, and Transmissible Presenile Dementias 15 D. Garteton Gajdusek and Glarence J. Gibbs, Jr. Discussion I Chapters 1-2 50 Comment I Chapters 1-2 by G. A. Mims 52 Chapter 3 Sheep Progressive Pneumonia Viruses 54 Donald H.

Spis treści

Unconventional Agents.- Scrapie: Pathogenesis in Inbred Mice: An Assessment of Host Control and Response Involving Many Strains of Agent.- Kuru, Creutzfeldt-Jakob Disease, and Transmissible Presenile Dementias.- Discussion/Chapters 1–2.- Comment/Chapters 1–2.- Sheep Progressive Pneumonia Viruses.- Discussion/Chapter 3.- Comment/Chapter 3.- Comment/Chapter 3.- Conventional Agents.- Borna, the Disease—A Summary of Our Present Knowledge.- Borna Disease: Patterns of Infection.- Discussion/Chapters 4–5.- Progressive Multifocal Leukoencephalopathy.- Discussion/Chapter 6.- Comment/Chapter 6.- Subacute Sclerosing Panencephalitis.- Comment/Chapter 7.- A Concept of Virus-Induced Demyelinating Encephalomyelitis Relative to an Animal Model.- Comment/Chapter 8.- The Biologic Role of Host-Dependent Proteolytic Cleavage of a Paramyxovirus Glycoprotein.- Discussion/Chapter 9.- Comment/Chapter 9.- Multiple Sclerosis.- Multiple Sclerosis: A Case for Viral Etiology.- In Search of the Abominable Snowman or “deine Viren, meine Viren” in Multiple Sclerosis.- Characterization of the Virus Antibody Activity of Oligoclonal IgG Produced in the Central Nervous System of Patients with Multiple Sclerosis.- Discussion/Chapters 10–12.- Demyelination in Experimental Allergic Encephalomyelitis and Multiple Sclerosis.- Genetic Aspects of Multiple Sclerosis.- Cell-Mediated Immunity in Multiple Sclerosis.- Discussion/Chapters 13–15.- Comment/Chapters 13–15.- Critique on the Investigational Approaches to Etiology and Pathogenesis.- The Virologist.- Temperature-Sensitive Viruses: Possible Role in Chronic and Inapparent Infections.- Discussion/Chapters 16–17.- The Geneticist.- Discussion/Chapter 18.- Critique: Afterthoughts of an Immunologist.- Discussion/Chapter 19.- Critique: The Epidemiologist.- Discussion/Chapter 20.- Comment/Chapter 20.- Conclusions: Outlook on Future Research.