Skin Tissue Engineering and Regenerative Medicine

ISBN-13: 9780128016541 / Angielski / Miękka / 2016 / 466 str.

Mohammad Z. Albanna; James H. Holmes IV

Opis

The skin is the largest human organ system. Loss of skin integrity due to injury or illness results in a substantial physiologic imbalance and ultimately in severe disability or death. From burn victims to surgical scars and plastic surgery, the therapies resulting from skin tissue engineering and regenerative medicine are important to a broad spectrum of patients. Skin Tissue Engineering and Regenerative Medicine provides a translational link for biomedical researchers across fields to understand the inter-disciplinary approaches which expanded available therapies for patients and additional research collaboration. This work expands on the primary literature on the state of the art of cell therapies and biomaterials to review the most widely used surgical therapies for the specific clinical scenarios.

• Explores cellular and molecular processes of wound healing, scar formation, and dermal repair
• Includes examples of animal models for wound healing and translation to the clinical world
• Presents the current state of, and clinical opportunities for, extracellular matrices, natural biomaterials, synthetic biomaterials, biologic skin substitutes, and adult and fetal stem and skin cells for skin regenerative therapies and wound management
• Discusses new innovative approaches for wound healing including skin bioprinting and directed cellular therapies

Spis treści

ForewordIntroduction1. Anatomy, Physiology, Histology, & Immunohistochemistry of Human Skin 2. Molecular & Cellular Biology of Wound Healing and Skin Regeneration 3. Tissue Processing and Staining for Histological Analyses4. Clinical Management of Wound Healing and Hypertrophic Scarring 5. Process development & Manufacturing of Human and Animal Acellular Dermal Matrices 6. Clinical Applications of Acellular Dermal Matrices in Reconstructive Surgery 7. Advances in Acellular Extracellular Matrices (ECM) for Wound Healing 8. Natural Biomaterials for Skin Tissue Engineering 9. Synthetic Biomaterials for Skin Tissue Engineering 10. Hybrid Biomaterials for Skin Tissue Engineering 11. Biologic Skin Substitutes 12. Wound Healing: A Comprehensive Wound Assessment and Treatment Approach 13. Current Innovations for the Treatment of Chronic Wounds 14. The Surgical Management of Burn Wounds 15. Advances in Isolation and Expansion of Human Cells for Clinical Applications16. Cutaneous Applications of Stem Cells for Skin Tissue Engineering 17. Advances in Biopharmaceutical Agents & Growth Factors for Wound healing & Scarring18. Skin Models for Drug Development & Biopharmaceutical Industry 19. Animal Models for Wound Healing 20. Human Skin Bioprinting: Trajectory & Advances 21. Translational Research of Skin Substitutes & Wound Healing Products

O autorze

Dr. Albanna is currently the R&D Projects Lead and supervisor of the R&D department at COOK General BioTechnology, LLC, a COOK Medical company. Dr. Albanna was the team leader of skin Bioprinting clinical research programs at Wake Forest Institute for Regenerative Medicine (WFIRM) working on utilizing autologous and allogeneic skin and stem cells for developing dermal/epidermal skin substitutes. Dr. Albanna expedited the transition of multiple skin bioprinting projects from bench-top into clinics through development of preclinical models for wound healing and skin regeneration, protocols for large scale expansion of skin and stem cells for clinical use. Dr. Albanna has several years of expertise in product development of tissue-engineered products including skin wound healing products. He is author or the co-author of several patents and publications including book chapters and peer-reviewed journals in esteemed journals in the field of tissue engineering and regenerative medicine including two recent accepted book chapters on biomaterials for skin regeneration and acellular dermis matrices for skin regeneration and surgical reconstruction to be published in 2014 in Encyclopedia of Biomedical Polymers and Polymeric Biomaterials along with Dr. Holmes as a senior author. Dr. Holmes is an Associate Professor of Surgery and the Director of Wake Forest Baptist Medical Center (WFBMC) Burn Center. He is the current Chair of the American Burn Association (ABA) Southern Region. He is acting as the leading principal investigator for multiple burn clinical trials and is the current Chair of the ABA Multicenter Trials Group Burn Science Advisory Panel. He is co-author of an ABA white paper on the medical practice of treatment of wounds. He is author of many peer-reviewed journal papers and book chapters in the field of burns and wound healing.