Site Specific and Global Epigenomic Editing: Principles and Applications

ISBN-13: 9780128193983 / Angielski / Miękka / 2026

Feng C. Zhou; Trygve Tollefsbol

Spis treści

Part I EPIGENETICS AND EPIGENOMICS
1. Epigenetic editing: Progress and Challenges
2. Epigenetic dynamics: Normal progression and abnormal alteration
3. Epigenomic landscape
4. Histone coding and its compounding influence on gene expression
5. microRNA as a tool for gene regulation
6. RNA editing and genetic influence
7. Epitranscription: Scope and engineering ability

Part II GLOBAL EPIGENETIC EDITING
8. Global epigenetic editing uses methods of DNA methylation alteration drugs
9. Regulating DNA methylation for developmental disorders
10. Histone modification drug the HDACi: Selectivity and promise
11. Histone modification in cancer treatment
12. Alteration of DNA Methylation in gastric cancer
13. Epigenetic therapy for the treatment of epithelial ovarian cancer
14. Epigenetic application on allergy treatment
15. HDACi therapy for the treatment of depression
16. Histone modification on neurodevelopmental and neuropsychiatric disorders
17. Epigenetics and Addiction
18. Epigenetic Treatment of Persistent Viral Infections
19. MicroRNA as strategy of gene regulation

Part III SITE SPECIFIC EPIGENETIC EDITING
20. Strategy and Molecular tools for site-specific editing
21. Site-specific recruitment of epigenetic factors for spatio-temporal epigenetic editing.
22. Monitoring CRISPR-Cas9 mediated DNA-methylation-editing
23. Locus-specific editing of histone modifications
24. Functional DNA methylation and epigenetic editing on proneuron genes during neuroglial differentiation
25. Epigenetic editing through regulating CRISPR-Cas9 mediated non-coding RNA
26. Epigenetic editing targeting a parkinsonian gene 
27. Cancer gene epigenetic editing
28. Epigenetic editing to unveil epigenetic mechanism of breast cancer
29. Editing DNA Methylation on Fragile X syndrome
30. Can RNA editing be engineered?
31. Genetic and epigenetic interactive approaches

Part IV TRANSLATIONAL AND CLINIC APPLICATION
32. Tuning DNA methylation in treating breast cancer:
33. Imminent Epigenetic editing in cancer treatment
34. Epigenetic editing for developmental disorders
35. Epigenetic editing on genetic imprinting
36. Prospective epigenetic treatment on Neurological disease
37. Epigenetic alterations and personalized treatment in cancer

Part V CLOSING VIEW
38. Obstacles and prospective of changing epigenetic codes
39. Ethical matters in modification of epigenetic codes
40. Future epigenetic treatment