Sirtuins

ISBN-13: 9789402414509 / Angielski / Miękka / 2018 / 288 str.

Riekelt H. Houtkooper

Spis treści

General introduction

Riekelt H. Houtkooper

Biochemistry and Enzymology of Sirtuins

Yue Yang and Anthony A. Sauve

NAD+ as a pharmacological tool to boost sirtuin activity

Riekelt H. Houtkooper

Protein lysine acylation: abundance, dynamics and function

Olga Pougovkina and Vincent C. J. de Boer

SIRT1 in metabolic health and disease

Marie Boutant and Carles Cantó

Deacetylation by SIRT3 relieves inhibition of mitochondrial protein function 

Peter Chhoy, Kristin A. Anderson, Kathleen A. Hershberger, Frank K. Huynh, Angelical S. Martin, Eoin McDonnell, Brett S. Peterson, Laura A. Starzenski, Donald S. Backos, Kristofer S. Fritz, and Matthew D. Hirschey

SIRT5 reveals novel enzymatic activities of sirtuins

Bin He and Hening Lin

Diverse roles for SIRT6 in mammalian healthspan and longevity

Bernadette M. M. Zwaans, William Giblin and David B. Lombard

Sirtuins in cancer – emerging role as modulators of metabolic reprogramming

Jaewon J. Lee, Karina N. Gonzalez Herrera and Marcia C. Haigis

Sirtuins as metabolic modulators of muscle plasticity

Keir Menzies, Julien Francisco Zaldivar-Jolissaint and Johan Auwerx

Sirtuins and aging

Carles Cantó and Riekelt Houtkooper

Sirtuins and the Circadian Clock: Epigenetic and Metabolic Crosstalk 

Selma Masri, Marina Maria Bellet and Paolo Sassone-Corsi

Sirtuin activation by small molecules

Hassina Massudi, Lindsay E. Wu, and David A. Sinclair

Future perspective

Brian Kennedy

Index

Blurb

The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease.