Silibinin anti-tumor effects at a glance

ISBN-13: 9786139471843 / Angielski

Mahdi Mashhadi Akbar Boojar

Opis

Silibinin is a major component of silymarin (Silybum marianum), which has traditionally been used to treat a wide range of liver diseases. Recently, Silibinin and its derivatives in both in vitro and in vivo models have shown a significant inhibitory effect in different types of tumors including skin, breast, lung, colon, bladder, prostate, kidney and liver. The chemo-preventive potentials of this flavonoid are promoted by inducing apoptosis, enhancing tumor suppressor and cell cycle inhibitors, inhibiting growth factors, and attenuating proliferative mediators. In this paper, a summary of the important molecular mechanisms involved in Silibinin anti-cancer effects, animal studies and important clinical trials have been presented. The results of these studies will provide a more comprehensive perspective of Silibinin and help to optimize its effects in cancer chemotherapy.

O autorze

Mashhadi Akbar Boojar, Mahdi
Mahdi Mashhadi Akbar Boojar (Pharm.D., Ph.D.) received his Doctorate in Pharmacology, from Tehran University of Medical Sciences, Iran in 2016. Dr. Mahdi Mashhadi Akbar Boojar currently works at the Department of Pharmacology and Toxicology, Baqiyatallah University of Medical Sciences, Tehran, Iran.