Signaling Pathways in Squamous Cancer

ISBN-13: 9781441972026 / Angielski / Twarda / 2010 / 462 str.

Adam B. Glick; Carter Van Waes

Opis

Squamous epithelia form the lining surface of tissues in contact with the environment: the skin, oral mucosa, esophagus and respiratory tract, the genital tract, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV, tobacco smoke and infectious agents. Cancers that form in squamous epithelia are among the most common human solid tumors and have high morbidity and mortality. These cancers include squamous cell carcinoma of the skin, oral cancer, head and neck and esophageal cancer, certain lung cancers and cervical cancer. We propose to organize the book so that the early chapters will focus on individual pathways and more specific mechanisms in both normal function and cancer, while the later chapters will be more integrative and include overviews of biomarkers and therapeutic development. This should increase interest for clinically oriented researchers. All authors will be encouraged to provide a balanced review in addition to highlighting their own work.

Spis treści

Signaling Pathways in Squamous Cancer Chapter 1. Cell Adhesion Molecules in Carcinoma Invasion and Metastasis Ziober, Humtsoe and Kramer Chapter 2. Roles of Integrins in the Development and Progressio of Squamous Cell Carcinoma Lamar and DiPersio Chapter 3. Alterations in Transforming Growth Factor beta Signaling in Squamous Cell Carcinomas Xie and Riess Chapter 4. Aberrant Activation of HGF/c-MET Signalign and Targeted Therapy in Squamous Cancer Chen Chapter 5. The Epidermal Growth Factor Receptor in normal and Neoplastic Epithelia Repertinger, Madson, Bischel and Hansen Chapter 6. Cyclooxygenase-2 Signaling in Squamous Cell Cancer Rundhaug and Fischer Chapter 7. Interacting Signaling Pathways in Mouse Skin Tumor Initiation and Progression Cataisson and Yuspa Chapter 8. Protein Kinase C and the Development of Squamous Cell Carcinoma Denning Chapter 9. The Transcription factor AP-1 in Squamous Cell Carcinogenesis: Lessons From Mouse Models of Skin Carcinogenesis Hess and Angel Chapter 10. NF-kB and IkB Kinases in Squamous Cancers Costanzo, Spallone and Karin Chapter 11. Regulation of Squamous Cell Carcinoma Carcinogenesis by Peroxisome Proliferator-Activated Receptors (PPARs) Peters and Gonzalez Chapter 12. p63 in Squamous Differentiation and Cancer Roop and Koster Chapter 13. Effects of Natural and Synthetic Retinoids on the Differnetiation and Growth of Squamous Cancers Kadara and Lotan Chapter 14. Regulation of Keratinocyte Differnetiation by Vitamin D and its Relationship to Squamous Cell Carcinoma Teichert and Bickle Chapter 15. Epidermal Growth Factor Receptor-Targeted Therapies Ahn, Kin and Grandis Chapter 16. Targeting UVB Mediated Signal Transduction Pathways for the Chemoprevention of Squamous Cell Carcinoma Bowden and Alberts Chapter 17. Molecular Targeted Chemotherapy for Head and Neck Squamous Cell Carcinoma Lin and Rocco Chapter 18. Effects and Therapeutic Potential of Targeting Dysregulated Signaling Axes in Squamous Cell Carcinoma:AKT and MTOR Clark, Ekshyyan and Nathan Chapter 19. Head and Neck Cancer and the PI3K/AKT/mTOR Signaling Network: Novel Moleuclar Targeted Therapies Amornphimoltham, Patel, Molinolo and Gutkind Chapter 20. High Throughput Molecular Profiling Approaches for the Identification of Genomic Alterations and Therapeutic Targets Zhou, Hu and Wong

Blurb

Squamous epithelia form the essential lining surface of tissues in contact with the environment, including the skin, and mucosa of the oral cavity, pharynx, larynx, esophagus, respiratory and genital tracts, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV light, tobacco smoke, and infectious agents. Consequently, squamous cell carcinomas that form in these tissues are among the most common human solid tumors, and have high morbidity and mortality. The signaling pathways that regulate epithelial homeostasis and the alterations in these pathways that arise during cancer development share certain features among these different tissue sites. This book brings together timely reviews from experts in the field on mechanisms and signaling pathways such as EGFR, TGF1, NFB, PPARs and mTOR/AKT that regulate development of squamous cancer in both human and experimental mouse models, with a focus on how these specific signaling pathways can be utilized as targets for anti-cancer therapy. This comprehensive monograph will be important for researchers wishing to enter the field, for medical students, and for established basic and clinical investigators who would gain from an overview of the field.