Signaling Mechanisms of Oxygen and Nitrogen Free Radicals

ISBN-13: 9780367385569 / Angielski / Miękka / 2019 / 220 str.

Igor B. Afanas'ev

Opis

Exploring major questions regarding signaling mechanisms of reactive oxygen and nitrogen species (ROS/RNS) in enzymatic processes, this volume investigates free radical signaling processes catalyzed by enzymes and examines those producers of superoxide and nitric oxide that use ROS/RNS as signaling species to initiate the process. It considers ROS/RNS sufficiency of signaling production by mitochondrial enzymes, key findings in mitochondrial disorders and subsequent apoptosis, and the development of new treatment potentials for age-related afflictions such as inflammation, cancer, and cardiovascular disease.

Spis treści

Introduction. Formation of superoxide by major enzyme-catalyzed reactions. Formation of nitric oxide by no synthases. Formation of reactive oxygen and nitrogen species originated from superoxide and nitric oxide. Mechanisms of nucleophilic and one-electron transfer reactions of superoxide and NO. Signaling functions of superoxide and nitric oxide in heterolytic (nucleophilic) reactions. Mitochondrial disorders initiated by reactive oxygen and nitrogen species. Antagonistic signaling by superoxide and nitric oxide in pathological processes. Participation of superoxide and nitric oxide in apoptosis. Competition between superoxide and nitric oxide in aging and senescence.

O autorze

Afanas'ev, Igor B.