Signal Transduction in Photoreceptor Cells: Proceedings of an International Workshop Held at the Research Centre Jülich, Jülich, Fed. Rep. of Germany,

ISBN-13: 9783540537656 / Angielski / Miękka / 1992 / 318 str.

Paul A. Hargrave; Klaus P. Hofmann; U. Benjamin Kaupp

Opis

This book deals with the mechanism of signal transduction in vertebrate and invertebrate photoreceptors. It contains contributions on the structure and function of rhodopsin or other G-coupled receptors, on the regulation of second messengers by enzyme cascade, the role of Ca2+ in light adaptation, control of ionic channels in photoreceptor cells.

Spis treści

Hermann Kühn — In Memoriam.- Plenary Lecture.- The Eyes of Halobacteria.- I Rhodopsin — Structure and Function.- Mutagenesis Studies of Rhodopsin Phototransduction.- Structural Stability of Rhodopsin and Opsin Studied by Differential Scanning Calorimetry.- Molecular Analysis of Photoreceptor Protein Function.- Octopus Rhodopsin.- II Transducin and Phosphodiesterase.- The Activation of Transducin: Studies on its Mechanism and Modulation.- The Transitory Complexes Between Photoexcited Rhodopsin and Transducin. Biochemical and Spectroscopic Studies.- The Rate of GTP Hydrolysis by Transducin and the Termination of the cGMP Cascade in Retinal Rods.- The Molecular Biology of the Rod Photoreceptor cGMP Phosphodiesterase ?- and ?-Subunits.- III Deactivation Mechanisms.- The Phosphorylation of Rhodopsin.- Mechanisms of ?-Adrenergic Receptor Desensitization.- IV The cGMP-gated Channel.- Gating Kinetics of the cGMP-Activated Conductance of Retinal Cones.- Molecular Properties of the cGMP-gated Cation Channel of Rod Photoreceptor Cells as Probed with Monoclonal Antibodies.- Cyclic Nucleotide-gated Channels — A Family of Proteins Involved in Vertebrate Photoreception and Olfaction.- V Ca2+ Metabolism and Light Adaptation.- Interactions Between Calcium and cGMP in Dialyzed Detached Retinal Rod Outer Segments.- The Role of Cytoplasmic Calcium Concentration in Photoreceptor Light Adaptation.- Photoreceptor Guanylate Cyclase and Its Regulation by Calcium.- VI Transduction in Invertebrates.- Cyclic-GMP Phosphodiesterase in Photoreceptor Cells in Limulus Ventral Eye.- The Molecular Mechanism of Retinal Degeneration in the Retinal Degeneration B (rdgB) Mutant of Drosophila.- Glycosylation of Dipteran Opsins During Membrane Biogenesis.- Molecular Genetics of Visual Transduction in Drosophila.- Index of Contributors.