Signal Transduction: Pathways, Mechanisms and Diseases

ISBN-13: 9783642021114 / Angielski / Twarda / 2009 / 437 str.

Ari Sitaramayya

Opis

Teachingagraduatecourseonsignaltransductioninthefallof2007wasvery enjoyable. Eachweek, mystudentsandIdiscussedarecentlypublishedresearch paperinsomeareaofsignaling, arguedabouttheappropriatenessofthemethod- ogyusedintheresearch, thedesignoftheexperiments, andwhethertheconc- sions drawn were supported bythe results presented. Finally, each student was askedtolistwhatwasgoodandwhatwasde?cientinthepaperandwhethershe/he wouldhaveacceptedorrejectedithadshe/herevieweditforpublication. Fora goodnumberofrecentpapers, aconsistentcomplaintofthestudentswasthatthe backgroundtotheresearchwasnotadequatelydescribed. Itcanofcoursebeargued that students should research the background. Either way, the need for a good sourceofbackgroundmaterialinordertoappreciatetheresearchpresentedina paperbecameapparenttomeandwastheinspirationfordevelopingthisbook. Thegoalinbringingthisbookwastoprovidestudentswithareviewofrecent developmentsinspeci?careasofcurrentinterestinsignaltransduction, suf?ciently indepthtomakerecentresearchpublicationsaccessible. However, giventhewide rangeofresearchtopicsbeinginvestigatedtodayinsignaling, achoicehadtobe madetofocusonaselectfew. Thischoicewasmadenotonlykeepingthecurrent research interest in mind, but also with the anticipation that these areas will continuetobeofinterestoverthenextseveralyears. Inchoosingpapersfordiscussioninmyclass, Ilookforhealth-relatednessofthe research, andthatisre?ectedinthelistofthebroadareascoveredinthisbook G proteincoupledreceptors, growthfactors, nuclearreceptors, reactiveoxygenand nitrogenspecies, cellcycleandcancer;theemphasishasbeenonareasofsignaling researchwithimmediateclinicalsigni?cance. Ibelievethisbookwillservewellas supplementalreadingmaterialforundergraduateandgraduatestudentswithsimilar interest. Anotherareacoveredinthisbook, onenotoftenhighlightedinsignaltransd- tionbooks, isthatofsignalingplatforms, whichisemergingasasigni?cantareaof researchrelevanttocellularmetabolism, cellproliferation, differentiation, apop- sis, neurodegenerativediseases, andcancer. Theauthorscontributingtothisbook vii viii Preface areexpertsandactivecontributorstoresearchintheirspeci?careasofsignaling. I would like to thank them for their contributions and their suggestions in the developmentofthebook. IwouldliketoacknowledgethehelpofFrankTedeschi, astudentinmydepartment, whoassistedineditingthemanuscriptsandinprep- ingtheindex. IwouldalsoliketothankDr. SabineSchwarz, LifeSciencesEditorat SpringerVerlag, andDr. JuttaLindenbornwhohavebeenveryhelpfulatevery stageofproductionofthisbook. AriSitaramayya Contents PartI GProteinsandGProtein CoupledReceptors 1 TraditionalGPCRPharmacologyandBeyond. . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 AnnetteGilchristandMariaR. Mazzoni 2 RegulationofIntraneuronalTraf?ckingofG-Protein-Coupled ReceptorsbyNeurotransmittersInVivo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 VeroniqueBernard 3 SmallGTPasesandTheirRoleinRegulatingGProtein-Coupled ReceptorSignalTransduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 FabiolaM. RibeiroandStephenS. G. Ferguson 4 RegulationofGProteinReceptorCoupling, MoodDisorders andMechanismofActionofAntidepressants . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 MoranGolan, GabrielSchreiber, andSo?aAvissar 5 DysregulationofGProtein-CoupledReceptorSignaling inCancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83 JoAnnTrejo PartII GrowthFactors 6 InsulinSignalinginNormalandDiabeticConditions . . . . . . . . . . . . . . . . . 101 PatriceEFort, HisanoriImai, RajuRajala, andThomasW. Gardner 7 EpidermalGrowthFactor(EGF)ReceptorSignaling andCancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119 ElizabethS. HensonandSpencerB. Gibson ix x Contents 8 LeptinSignalingPathway. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143 HiroyukiShimizu 9 SignalinginNormalandPathologicalAngiogenesis. . . . . . . . . . . . . . . . . . 159 MichaelR. MancusoandCalvinJ. Kuo PartIII SignalingPlatforms 10 SpatialandTemporalControlofCellSignaling byA-KinaseAnchoringProteins. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 183 F. DonelsonSmith, LoreneK. Langeberg, andJohnD. Scott 11 Mitochondria, aPlatformforDiverseSignalingPathways . . . . . . . . . . 199 AstridC. SchaussandHeidiM. McBridee 12 Mitogen-ActivatedProteinKinases andTheirScaffoldingProteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219 DannyN. DhanasekaranandE. PremkumarReddy 2 13 MolecularandFunctionalDeterminantsofCa SignalingMicrodomains . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 237 InduS. Ambudkar, HweiL. Ong, andBrijB. Singh PartIV NuclearReceptors/Transcription 14 EukaryoticGeneTranscription . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 257 JenniferH. GromekandArikDvir 15 EstrogenSignalingMechanisms. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 273 DapengZhangandVanceL. Trudeau 16 SignalTransductionPathwaysInvolved inGlucocorticoidActions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289 PeterJ. Barnes PartV ReactiveSignalingMolecules 17 CellularSignalingbyReactiveOxygenSpecies: Biochemical BasisandPhysiologicalScope . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 313 MichelB. Toledano, SimonFourquet, andBeno?tD Autreaux 18 SolubleGuanylylCyclase: TheNitricOxideReceptor. . . . . . . . . . . . . . . 337 DorisKoeslingandAriSitaramayya Contents xi PartVI CellCycle, CellDeathandCancer 19 DistinctRolesofthePocketProteinsintheControl ofCellCycle. . . . . . . . . . . . . . . . . . . . . . . . . . .

Spis treści

G Proteins and G Protein–Coupled Receptors.- Traditional GPCR Pharmacology and Beyond.- Regulation of Intraneuronal Trafficking of G-Protein-Coupled Receptors by Neurotransmitters In Vivo.- Small GTPases and Their Role in Regulating G Protein-Coupled Receptor Signal Transduction.- Regulation of G Protein Receptor Coupling, Mood Disorders and Mechanism of Action of Antidepressants.- Dysregulation of G Protein-Coupled Receptor Signaling in Cancer.- Growth Factors.- Insulin Signaling in Normal and Diabetic Conditions.- Epidermal Growth Factor (EGF) Receptor Signaling and Cancer.- Leptin Signaling Pathway.- Signaling in Normal and Pathological Angiogenesis.- Signaling Platforms.- Spatial and Temporal Control of Cell Signaling by A-Kinase Anchoring Proteins.- Mitochondria, a Platform for Diverse Signaling Pathways.- Mitogen-Activated Protein Kinases and Their Scaffolding Proteins.- Molecular and Functional Determinants of Ca2+ Signaling Microdomains.- Nuclear Receptors / Transcription.- Eukaryotic Gene Transcription.- Estrogen Signaling Mechanisms.- Signal Transduction Pathways Involved in Glucocorticoid Actions.- Reactive Signaling Molecules.- Cellular Signaling by Reactive Oxygen Species: Biochemical Basis and Physiological Scope.- Soluble Guanylyl Cyclase: The Nitric Oxide Receptor.- Cell Cycle, Cell Death and Cancer.- Distinct Roles of the Pocket Proteins in the Control of Cell Cycle.- Activation of the p53 Tumor Suppressor and its Multiple Roles in Cell Cycle and Apoptosis.- Aging and Cancer: Caretakers and Gatekeepers.- Signal Transduction in Embryonic Stem Cells and the Rise of iPS Cells.- Erratum to.

Blurb

This book was adapted from graduate courses on signal transduction taught by the editor, where the need for a good overview of recent developments on each of the topics being discussed became apparent. Given the wide range of research topics in signaling, a selection was made that not only reflects the current research interest, but also anticipates those areas that will continue to be of interest over the next several years.

The health-relatedness of research was a major criterion for selection, as can be seen in the list of topics covered, such as G protein coupled receptors, growth factors, nuclear receptors, reactive oxygen and nitrogen species, the cell cycle and cancer. The emphasis is on areas of signaling research with direct clinical significance. Another field covered, one rarely highlighted in signal transduction books, is that of signaling platforms, which has been emerging as a significant research area relevant to cellular metabolism, cell proliferation, differentiation, apoptosis, neurodegenerative diseases, and cancer.