Side-Effects of Anti-Inflammatory Drugs: Part One Clinical and Epidemiological Aspects

ISBN-13: 9789401097741 / Angielski / Miękka / 2012 / 352 str.

K. D. Rainsford; G. P. Velo

Opis

These two volumes contain the proceedings of a 3 day international meeting held at the University of Cambidge and Queens' College Cambridge from 31st July to 2nd August 1985 on the Side-Effects of Anti-Inflammatory Analgesic Drugs. The first meeting was held in Verona, (Italy) in 1982 and the organisers felt that, with a number of recent developments including the withdrawal of a num- ber of new anti-inflammatory drugs, and concern being expressed in the lay and specialist medical press and other media about the safety of these drugs, that it was appropriate to have a second such meeting. The meeting was attended by some 300 delegates and the dis- cussion focussed most intently on the recent issues, e. g. the value of adverse drug reaction reporting of the non-steroidal anti- inflammatory (NSAI) drugs, certain side-effects associated with particular NSAI drugs, the predictive value of animal models etc. Organising a meeting de novo without outside help would not have been possible without the immensely valuable help given en- thusiastically by people and financial assistance given most generously by those pharmaceutical companies listed below. These financial contributions were given despite current economic dif- ficulties and moves to restrict the proportion of profits towards educational activities.

Spis treści

1 Table of Contents.- Section I Clinical and Epidemiological Aspects.- 1 Introduction and historical aspects of the side-effects of anti-inflammatory analgesic drugs.- 2 Epidemiology in the United Kingdom of adverse drug reactions from non-steroidal anti-inflammatory drugs.- Discussion.- 3 Assessment of adverse reactions to NSAIDs: Pre- and post-marketing..- Discussion.- 4 Incidence of serious side effects from non-steroidal anti-inflammatory drugs (NSAIDs) in the USA.- Discussion.- 5 Trends and patterns in adverse drug reactions to non-steroidal anti-inflammatory drugs reported in Sweden.- Discussion.- 6 Rare adverse reactions to non-steroidal anti-inflammatory drugs.- Discussion.- 7 Pyrazolone-induced agranulocytosis: an epidemiological evaluation.- Discussion.- 8 Potential biases influencing interpretation of data from worldwide spontaneous ADR reports.- Discussion.- 9 Prescription-event monitoring of five non-steroidal anti-inflammatory drugs.- Discussion.- 10 Side-effects of non-steroidal anti-inflammatory drugs in children with juvenile rheumatoid arthritis.- Discussion.- 11 Non-steroidal anti-inflammatories: outpatient audit of patient preferences and side-effects in different diseases.- Discussion.- 12 Non-steroidal anti-inflammatories in the elderly.- Discussion.- 13 Ibuprofen overdose — the first year following over-the-counter release.- Discussion.- Section II Drug Interactions and Drug Metabolism.- 14 Drug interactions between the anti-inflammatory drugs and with other agents.- Discussion.- 15 Interactions between non-steroidal anti-inflammatory drugs and angiotensin converting enzyme inhibitors in man.- Discussion.- 16 Responders and non-responders to NSAI drug interactions a neglected problem?.- Discussion.- 17 Biological implications of the metabolic chiral inversion of 2-arylpropionic acid non-steroidal anti-inflammatory drugs.- Discussion.- 18 A medicinal chemist’s perspective of side-effects of anti-inflammatory analgesic drugs.- Discussion.- 19 Genetic and environmental aspects of drug metabolism relevant to side-effects in arthritic disease.- Discussion.- 20 Disease drug interactions: utility of the conditional concept for experimental pharmacology and toxicology in the context of inflammation.- Discussion.- 21 Pharmacokinetic profile of ketoprofen in elderly subjects.- 22 The effects of frusemide and Dorbanex on the pharmacokinetic profile of benoxaprofen in elderly subjects.- Discussion.- 23 Enantioselective dispositon of a model non-steroidal anti-inflammatory drug 2-phenylpropionic acid.- Section III Gastrointestinal Tract (Clinical Aspects).- 24 Anti-inflammatory drugs and upper gastrointestinal perforation.- Discussion.- 25 Piroxicam and gastrointestinal ulceration.- Discussion.- 26 Anti-inflammatory drugs and gastrointestinal disease. Reasons for the failure of adverse reaction reporting and surveillance systems to detect a significant association.- Discussion.- 27 An evaluation of the frequency of anti-inflammatory and analgesic drug intake among patients with acute gastrointestinal bleeding.