Short Course Breast Radiotherapy: A Comprehensive Review of Hypofractionation, Partial Breast, and Intra-Operative Irradiation

ISBN-13: 9783319243863 / Angielski / Twarda / 2016 / 501 str.

Douglas W. Arthur; Frank Vicini; David E. Wazer

Recenzje

"It is sometimes good to take stock of a situation and of the four major issues in breast radio therapy viz. hypofractionation, partial breast radiation, intraoperative radio therapy and extent of nodal radiation. The first three are comprehensively reviewed in this excellent and well referenced book. ... Overall an excellent book for the shelves of every evidenced base breast radiation oncologist." (Dr. Nick Plowman, RAD Magazine, September, 2016)

Spis treści

Section I:

1.Accelerated Breast Irradiation: History, Rationale, and Controversies

2.Pathologic Anatomy of Early-Stage Breast Cancer: Defining the Target

3.The Radiobiology of Accelerated Breast Irradiation

4.Quality Assurance and Radiation Safety/Medical Events 

5.Surgical Considerations in Partial Breast Irradiation

6.Impact of Oncoplastic Surgery on adjuvant XRT

7. Comparison of true cost between modalities in a changing health care system

SECTION II:  Hypofractionated WBI

8. Patient Selection

9. Physics of HWBI

10. Treatment History- techniques/data/toxicity

SECTION III: APBI

11. Patient Selection

12. Physics of Accelerated Partial Breast Irradiation

13. Interstitial brachytherapy – techniques/data/toxicity                                        

14. Intracavitary brachytherapy – techniques/data/toxicity

15. 3D-Conformal external beam radiotherapy  - techniques/data/toxicity

SECTION IV: IORT

16. Patient Selection

17. Physics of IORT

18. 50 kV Photons: Targeted Intraoperative Radiotherapy (TARGIT) - techniques/data/toxicity

19. Intraoperative Technique with Electrons-  techniques/data/toxicity

SECTION V: Emerging treatment approaches             

20. Extreme hypofractionation

(brachytherapy, Gammapod, UK FAST WBI)               

21. APBI for breast augmentations              

22. Accuboost                

23. APBI for in-breast recurrence following WBI                          

24. Preoperative partial breast

25.  Locoregional Hypofractionation

SECTION VI: Hypofractionation for metastatic disease

26.Stereotactic treatment for Oligometastatic disease

27.Hypofractionaton for palliation

• Bone mets - palliative
  
• Visceral mets - palliative
  
• Chest wall/localregional recurrence 
  

 

 

O autorze

Dr. Arthur is currently Professor and Vice Chairman of the  Department of Radiation Oncology , Virginia Commonwealth University. His clinical and research interests include brachytherapy, management of breast and genitourinary malignancies, and soft tissue malignancies. Dr Arthur’s primary research interests include clinical studies focusing on the treatment of breast cancer with special interest in the development and use of accelerated treatment for breast cancer.  He is a breast committee member of the NRG Oncology national cooperative trial group.  

Dr. Frank Vicini has held multiple academic appointments and authored over 200 peer-reviewed articles. He is involved in numerous clinical studies being the Principal Investigator of several with the goal of improving therapeutic outcomes for all stages of breast cancer, reducing cancer treatment times and minimizing toxicities of healthy tissues and vital organs. He is also listed as one of the few oncologists in "Best Oncology Doctors in America."

David E. Wazer, MD is chief of radiation oncology for the Lifespan Healthcare System in New England and divides his time between Rhode Island Hospital and Tufts Medical Center in Boston. He is professor and chairman of radiation oncology at both Tufts University School of Medicine and The Alpert Medical School of Brown University. Dr. Wazer has numerous sc

ientific publications, co-edits the premier textbook for radiation oncology,  serves as Editor-in-Chief of the American Journal of Clinical Oncology, and actively conducts clinical and cost/utility research in breast cancer, brachytherapy, melanoma, and several novel radiation therapy technologies. 

Dr. Khan has been at the Cancer Institute of New Jersey since 2007 after completing a fellowship in brachytherapy at the Brigham and Women’s Hospital at Harvard. Prior to that, he completed a residency in radiation oncology at Rush University Medical Center. Dr. Khan’s primary focus has been in breast cancer, as well as radiation therapy for central nervous system/brain tumors.  Dr Khan is interested in the discovery of novel radiosensitizers and in advanced modalities of highly conformal radiotherapy, such as image-guided brachytherapy and proton therapy.   

Blurb

This comprehensive handbook on the implementation of short course radiotherapy for the treatment of breast cancer is intended as an up-to-date resource for the clinician. The book opens with a series of chapters on underlying principles and diverse relevant topics, including pathologic anatomy of early-stage breast cancer, radiobiology of accelerated breast irradiation, quality assurance and radiation safety, surgical considerations in partial breast irradiation, and impact of oncoplastic surgery on adjuvant radiotherapy. Individual sections are then devoted to hypofractionated whole breast radiotherapy, accelerated partial breast irradiation, and intraoperative radiotherapy. Each section includes details of patient selection, physics, techniques, data, and toxicity.  The reader is provided with clear guidance on the appropriate use of accelerated forms of adjuvant radiotherapy for treatment of early-stage breast cancer and on various emerging treatment approaches.