1. Historical and conceptual approaches to addiction Ed Day and James Morris; 2. Illicit drug use: epidemiology, aetiology and prevention Ed Day; 3. Illicit drug use: clinical features and treatment Ed Day; 4. Addiction to prescription medication: benzodiazepines, Z-drugs and gabapentinoids Emma Rourke and Fergus Law; 5. Alcohol use disorders: epidemiology and prevention Paul Bogowicz, Eilish Gilvarry, Andrea Hearn and Eileen Kaner; 6. Alcohol use disorders: aetiology and pathophysiology Nicola J. Kalk and Mary Thornton; 7. Alcohol use disorders: clinical features and treatment Duncan Raistrick and Gillian Tober; 8. Psychological approaches to addiction Rob Hill and Jennifer Harris; 9. Co-morbid substance use and mental illness Michael Kelleher; 10. Medical aspects of drug and alcohol use David Pang and Mark Pucci; 11. Organising treatment services for drug and alcohol misusers Emily Finch; 12. Tobacco use disorders Debbie Robson and Ann McNeil; 13. Novel psychoactive substances (NPS) and club drugs Dima Abdulrahim and Owen Bowden-Jones; 14. Addiction problems in a family and social context Alex Copello and Ed Day; 15. Addiction recovery mutual-aid organizations John F. Kelly, Alexandra Abry and Brandon G. Bergman.