Selenium and Burkitt Lymphoma incidence in Western Kenya : Selenium micro-nutrient and Childhood Cancer in Western Kenya

ISBN-13: 9783846546758 / Angielski / Miękka / 2011 / 140 str.

Odada Peter Sumba; Ephantus Kabiru; Rosemary Rochford

Opis

Cancer is emerging to be a major problem in Kenya. It is a multi-step process and not much is known in the causal matrix. Cases of non-Hodgkin lymphoma are very common in malaria holo-endemic areas a long the Lake Victoria Basin. The only suspected etiological agents for this cancer (Burkitt Lymphoma (BL)) are Epstein-Barr virus (EBV) and holoendemic Plasmodium falciparum malaria. However, recent BL incidence show a more refined spatial clusters within the region that strongly suggest the existence of co-factors. One such co-factor investigated GPx was selenium. This publication outlines the findings of the study on GPx selenium, a surrogate of the body nutritional status. It is known to regulate hormonal and enzymatic pathways, reactive oxygen species (ROS)and DNA repairs. Its deficiency potentiate microbial mutations and increased risk of BL pathogenesis.

O autorze

I am senior scientist at Kenya Medical Research Institute. I obtained MPH degree at CWRU, USA and PhD in Public Health at Kenyatta University,Kenya. Rosemary Rochford is a professor of virology at SUNY Upstate university. EW Kabiru is a professor of parasitology at Kenyatta University. Publication of this book fulfills a long dream.