Ruthenium Chemistry

ISBN-13: 9789814774390 / Twarda / 2018 / 386 str.

Opis

This book will describe Ruthenium complexes as chemotherapeutic agent specifically at tumor site. It has been the most challenging task in the area of cancer therapy. Nanoparticles are now emerging as the most effective alternative to traditional chemotherapeutic approach. Nanoparticles have been shown to be useful in this respect. However, in view of organ system complicacies, instead of using nanoparticles as a delivery tool, it will be more appropriate to synthesize a drug of nanoparticle size that can use blood transport mechanism to reach the tumor site and regress cancer. Due to less toxicity and effective bio-distribution, ruthenium (Ru) complexes are of much current interest. Additionally, lumiscent Ru-complexes can be synthesized in nanoparticle size and can be directly traced at tissue level.

The book will contain the synthesis, characterization, and applications of various Ruthenium complexes as chemotherapeutic agents. The book will also cover the introduction to chemotherapy, classification of Ru- complexes with respect to their oxidation states and geometry, Ruthenium complexes of nano size: shape and binding- selectivity, binding of ruthenium complexes with DNA, DNA cleavage studies and cytotoxicity.

The present book will be more beneficial to researchers, scientists and biomedical. Current book will empower specially to younger generation to create a new world of ruthenium chemistry in material science as well as in medicines. This book will be also beneficial to national/international research laboratories, and academia with interest in the area of coordination chemistry more especially to the Ruthenium compounds and its applications.

Spis treści

An Introduction to Ruthenium Chemistry. Ruthenium in Medicinal Chemistry. An overview of Ru-complexes as a potential sensing agent. Ruthenium Compounds: A New Approach in Nanochemistry. Synthesis and characterization of copper-ruthenium composites. Orbital Tuning of Ruthenium Polyimine Complexes by Ligand Design: from Basic Principles to Applications. The development of Ru(II)-p-cymene complexes with pyridine derivatives as anticancer agents. Approaching Cancer therapy with Ruthenium complexes by their interaction with DNA. Ruthenium Aryl Sulfides Complexes. Tuning of Ruthenium-DMSO Complexes for a search of new anticancer agent.