1. Transforming health care2. Global and national infrastructures supporting digital health ecosystems3. Global collaborative leadership challenges and economic drivers4. Fragmented global standards development organisations5. Standards for digital health, known limitations, and procurement6. The knowledge-driven platform: Strategic technologies for a platform ecosystem approach7. Are professional guidelines and regulatory standards fit for purpose?8. Health data standards' limitations9. Quality data, design, implementation, and governance10. Guideline and knowledge management in a digital world11. Modelling clinical knowledge12. Identity-What is in a name?13. Electronic health records and essential technology paradigms14. Health data security and privacy challenges: Solutions for the future15. The digital needs of genomics resulting from pandemics16. Health informatics in the Middle East and North Africa17. A framework for regional health information systems interoperability: Asia eHealth information network experiences18. The road to interoperability: openEHR modelling and implementation19. Evidence-based biomedical information systems: The road ahead20. Norway, Sweden, and Finland as forerunners in open ecosystems and openEHR21. The Brazilian digital health system: Building the digital transformation to engage country citizens22. Benefits of using SNOMED CT in the UK National Health Service (NHS)23. Primary health reform for the digital era24. Caribbean/PAHO-Jamaican case study25. Addressing workforce knowledge gaps in digital health26. Emerging digital health ecosystems