Rheumatoid Arthritis and Proteus

ISBN-13: 9780857299499 / Angielski / Miękka / 2011 / 244 str.

Alan Ebringer

Opis

Rheumatoid Arthritis and Proteus explores the idea that Rheumatoid arthritis is caused by a urinary tract infection as a result of Proteus bacteria. Rheumatoid arthritis is a severe, painful and crippling disease affecting millions of people throughout the world, especially women. Genetic studies over the last 30 years have shown that individuals who possess the white cell blood groups HLA-DR1/4 carry a susceptibility sequence and are more likely to develop the disease. This book uses the methods of Sir Karl Popper, the philosopher of science, to present 12 Popper sequences which have been identified to indicate that Proteus is the causative agent of Rheumatoid Arthritis. Rheumatoid Arthritis and Proteus proposes that Anti-Proteus therapies should be followed as early as possible to prevent the crippling and irreversible joint deformities that occur in Rheumatoid Arthritis.

Recenzje

From the reviews:

"This book explores the idea that rheumatoid arthritis (RA) is caused by a urinary tract infection as a result of Proteus bacteria. ... Medical students, rheumatology fellows, rheumatologists, and scientists will benefit from this book ... . This is an easy-to-read and informative book, with good charts and tables, on the relationship between Proteus bacteria and RA." (Richa Gupta, Doody's Review Service, April, 2012)

Spis treści

Scope and Distribution of the RA Problem.- History of the Attempts to Find the Cause of RA.- HLA-DR1/4 and Antibodies to Proteus in London.- Antibodies to Proteus in Irish patients with rheumatoid arthritis.- Antibodies to Proteus in rheumatoid arthritis patients from Bermuda and from Hertfordshire in England.- Antibodies to Proteus in rheumatoid arthritis patients from Brest and Toulouse in France.- Dutch patients with rheumatoid arthritis have antibodies to Proteus.- Anti-Proteus antibodies in Norwegian rheumatoid arthritis patients following a lactovegetarian diet.- Antibodies to Proteus in rheumatoid arthritis patients from Norway, Spain and England.- Antibodies to Proteus in rheumatoid arthritis  patients from southern Japan.- Urine Cultures and Correlation.- Molecular similarity between the “shared epitope” of rheumatoid arthritis and bacteria.- The “shared epitope”, Proteus haemolysin, XI collagen and rheumatoid arthritis.- Gram-negative bacteria possess sequences which resemble the “shared epitope”but only Proteus infect rheumatoid arthritis patients.- Immune responses to Proteus in rheumatoid arthritis patients from Finland and Japan.- Molecular similarity between the rheumatoid arthritis associated motif EQKRAA and structurally related sequences of  Proteus.- Rheumatoid arthritis sera are cytotoxic to cells bearing HLA and collagen susceptibility sequences.- The scientific method of Sir Karl Popper. Rheumatoid arthritis and “Popper sequences”.