Research in Medical and Biological Sciences: From Planning and Preparation to Grant Application and Publication

ISBN-13: 9780127999432 / Angielski / Miękka / 2015 / 584 str.

Petter Laake

Opis

Research in Medical and Biological Sciences covers the wide range of topics that a researcher must be familiar with in order to become a successful biomedical scientist. Perfect for aspiring as well as practicing professionals in the medical and biological sciences, this publication discusses a broad range of topics that are common yet not traditionally considered part of formal curricula, including philosophy of science, ethics, statistics, and grant applications. The information presented in this book also facilitates communication across conventional disciplinary boundaries, in line with the increasingly multidisciplinary nature of modern research projects.

• Provides a broad scientific perspective in basic, clinical and translational medical research, which is perfect for students with various professional backgrounds
• Contains easily accessible, concise material that makes learning about diverse methods achievable in today's fast-paced world
• Includes extensive examples, online resources such as further reading suggestions, and data files for statistical analyses
• Covers the breadth of topics, including research strategies, bibliographic tools and scientific communication, that a researcher must understand in order to be a successful scientist

Recenzje

"...an excellent conglomeration of practical information about research for medical researchers...may help streamline the work of researchers, saving time and energy while conserving limited resources. Score: 87 - 3 Stars" --Doody's

Spis treści

1. Philosophy of science

2. Ethics and scientific conduct

3. Ethics in human and animal studies

4. Research strategies, planning, and analysis

5. Literature search methods and bibliographic tools

6. Basic medical science

7. Translational medical research

8. Clinical research

9. Epidemiology

10. Qualitative research methods

11. Statistical inference

12. Evidence-based practice and systematic reviews

13. Scientific communication

14. Successful lecturing

15. Guide to grant applications

O autorze

Professor, PhD Petter Laake has since 1989 been a staff member of the Institute of Basic Medical Sciences, Department of Biostatistics, University of Oslo. He has 20 years of experience in lecturing, communicating and advising in statistics, at all levels and for various target groups. Since 2001, he has worked with the postgraduate studies programme at the Faculty of Medicine, University of Oslo, and has been in charge of the mandatory basic course in research methods. He has written and edited several text books in research methodology and statistics. Professor, MD Haakon Breien Benestad has since 1968 been a staff member of the Institute of Basic Medical Sciences, Department of Physiology, University of Oslo. He has lectured students of medicine, odontology, nutrition and physiotherapy and has been an advisor for master and postgraduate students. He has held various basic courses for postgraduate students, compiled compendia for these courses and written a textbook of anatomy, physiology and immunology for social and health studies in upper secondary schools. Dr. Bjorn R. Olsen, Hersey Professor of Cell Biology at Harvard Medical School and Professor of Developmental Biology at Harvard School of Dental Medicine, received his MD and PhD degrees in 1967 from the University of Oslo, Norway. In 1971, he moved to the United States and joined the faculty at Rutgers Medical School, now Rutgers Robert Wood Johnson Medical School, where he was Professor of Biochemistry from 1976 until he moved to Harvard Medical School in 1985 as Hersey Professor of Anatomy and Cell Biology.
Research in his laboratory has uncovered fundamental roles of collagens, transcription factors and receptors that affect skeletal development and homeostasis, angiogenesis and blood vessel morphogenesis. Work on the roles of extracellular proteins in tissue development led to discovery of several novel families of non-fibrillar collagens and uncovered disease mechanisms in many collagen-based osteochondrodysplasias and other disorders. Other studies identified mutations in the transcription factors HOXD13 and RUNX2 in polysyndactyly and cleidocranial dysplasia. Mapping of the genes for craniofacial disorders, such as cherubism and craniometaphyseal dysplasia led to identification of causative mutations in the siganling regulator SH3BP2, and the pyrophosphate transporter ANK. In research on pathogenetic mechanisms of vascular anomalies, the Olsen laboratory discovered that activating mutations in the receptor tyrosine kinase TIE2 cause venous malformations and identified mutations/ polymorphisms and signqling mechanisms associated with the rapid growth of infantile hemangioma, the most common tumor of infancy. By addressing questions related to skeletal development and vascular disease, the Olsen laboratory has been able to characterize complex developmental and disease mechanisms at the intersection between skeletal and vascular biology. This has recently led to new insights into unexpected intracellular mechanisms by which vascular endothelial growth factor A controls differentiation of mesenchymal stem cells to osteoblasts and adipocytes during bone development and postnatal repair.
Dr. Olsen has received many awards and honors, including Honorary Doctor of Science Degrees from the University of Medicine and Dentistry of New Jersey, University of Oslo, Norway, Okayama University, Japan, and Oulu University, Finland; Research Prizes and Awards from American Association of Anatomists, American Society of Matrix Biology, International Association of Dental Research, International Society of Matrix Biology and British Society for Matrix Biology. He is Fellow of American Association of Anatomists and American Association for the Advancement of Science, and he has been the elected organizer and chair of three different Gordon Research Conferences.