Regulation of Signal Transduction in Human Cell Research

ISBN-13: 9789811072956 / Angielski / Twarda / 2018 / 218 str.

Nariyoshi Shinomiya; Hiroaki Kataoka; Qian Xie

Opis

This book highlights several important key molecules and intracellular signaling pathways such as microRNA, the TGF-beta signaling pathway, the Wnt signaling pathway and MET signaling pathway as topical and highly relevant issues in human cell research related to signal transduction.

Spis treści

1. Regulation of microRNA expression by growth factors.- 2. TGF-b signaling and epithelial mesenchymal transition.- 3. Molecular designing of small molecule inhibitor for apoptotic pathways.- 4. Using genetically engineered mouse models to study Wnt signaling in bone development and disease.- 5. Glucose signaling and glycolysis.- 6. The interplay of tumor suppressor p53 with hypoxia-inducible factor-1 (HIF-1) at the crossroad between hypoxia-mediated cell survival and death.- 7. Role of G protein-coupled receptor signaling on the proliferation and differentiation of multipotent stem cells.- 8. Met-KO and carcinogenesis
9.  Clinical impact of MET pathway in cancer.- 10. Pericellular proteolytic activation of growth factors.

O autorze

Editors:

Nariyoshi Shinomiya

Department of Integrative Physiology and Bio‐Nano Medicine, National Defense Medical College, Tokorozawa, Japan

Hiroaki Kataoka

Department of Pathology, University of Miyazaki, Miyazaki, Japan

Qian Xie

Department of Biomedical Sciences, East Tennessee State University, Johnson City,

TN, USA