Regulation of Phosphate and Mineral Metabolism

ISBN-13: 9781468442618 / Angielski / Miękka / 2012 / 702 str.

Shaul G. Massry

Opis

We are pleased to present to our readers the Proceedings of the Fifth International Workshop on Phosphate and Other Minerals which was held in New York City, New York, U.S.A during September 23-27,1981. It was hosted by Joseph M. Letteri, M.D., Professor of Medicine at the State University of New York at Stonybrook School of Medicine, and Chief, Division of Nephrology, Nassau County Medical Center. As in the previous Workshops, this meeting provided an oppor- tunity for interested scientists from interrelated fields, including nephrology, endocrinology, physiology, biochemistry and nutrition, to get together and discuss the recent advances in the field of phosphate and mineral metabolism. There were 29 invited presenta- tions by leading scientists and 40 oral and 90 poster presentations selected from over 250 abstracts submitted to the Organizing Committee. The Workshop was attended by 250 scientists from 14 countries including Austria, Australia, Canada, Denmark, England, France, Germany, Holland, Israel, Italy, Japan, Sweden, and the United States of America. The Sixth International Workshop on Phosphate and Other Minerals will be held during June 24-26, 1983 in Verona, Italy. It will be hosted by Professor Giuseppe Maschio, Director, Division of Nephrology, Istituti Ospitalieri, Verona, Italy. The theme of this coming Workshop will continue to focus on the pathophysiology of phosphate homeostasis and the metabolism of other minerals.

Spis treści

I. Renal Handling of Phosphate.- The Adaptive System of the Tubular Transport of Phosphate.- Nephron Sites of Adaptation to Changes in Dietary Phosphate.- Phosphate Reabsorption in the Distal Convoluted Tubule.- Metabolic Abnormalities Underlying the Pathogenesis of Vitamin D Resistant Rickets (VDRR).- Relationship Between Plasma Phosphate and Renal Handling of Phosphate: Studies with Low Phosphate Diet and Nicotinamide.- Protein Phosphorylation in Proximal Tubular Brush-Border Membranes.- Possible Relationship of Gluconeogenesis to Modulation of Phosphate Transport in the Proximal Tubule.- Interactions Between Phosphate Transport and Oxidative Metabolism in the Rabbit Proximal Tubule.- Abnormal Tubular Pi Adaptation to Dietary Pi Restriction and Decreased Calcium Reabsorption in X-Linked Hypophosphatemic (HYP) Mice.- Renal Pi Transport in Young Growing and Adult Rats: Comparative Studies in Brush Border Membrane Vesicles (BBMV) and in Whole Kidney.- Difference in Renal Tubular Transport Effects of 1–34 and 1–84 Parathyroid Hormone (PTH).- 1,25-Dihydroxycholecalciferol (calcitriol): Effect on Phosphate (PO4) Absorption by Isolated Pars Recta.- In Vivo and In Vitro Effects of Vitamin D3 (1,25-(OH)2 D3) on the Uptake of Phosphate by Isolated Chick Kidney Cells.- Potassium Imbalance and Phosphate Renal Handling: A Micropuncture Study.- Renal Handling of Divalent Cations and Phosphate During Water Immersion in the Awake Dog.- The Effects of Calcium on ADH Action in Cortical Collecting Tubules Perfused In Vitro.- II. Phosphate Metabolism in Health and Disease.- The Creatine-Creatine Phosphate Shuttle for Energy Transport-Compartmentation of Creatine Phosphokinase in Muscle.- Hormonal Regulation of Phosphate Transport in the Differentiating Chick Small Intestine.- Measurement of Intracellular Inorganic Phosphate in Human Blood Red Cells, Leucocytes and Platelets.- Intracellular Inorganic Phosphate and ATP Levels in Human Blood Erythrocytes, Leucocytes and Platelets in Normal Subjects and in Diseases Associated with Altered Phosphate Metabolism.- Prevention of Phsophate Induced Progression of Experimental Uremia by 3-Phosphocitric Acid.- Phosphate Hemeostasis in Cimetidine Treated Uremic Dogs.- Regulation of Phosphate Excretion by the Diseased Kidney. The Intrinsic Proximal Tubular Adaptation.- Parathyroid Hormone Resistance in Renal Allograft Recipients.- III. Hypophosphatemia and Phosphate Depletion.- Models of Hypophosphatemia and Phosphate Depletion.- Effect of Phosphate Depletion on the Myocardium.- Hypophosphatemia and Osteoblast Function in Human Bone Disease.- Hypophosphatemia and Glucose Intolerance.- Acute Hypophosphatemia During Total Parenteral Nutrition in Man: Its Effects on Muscle Cell Composition.- Proximal Renal Tubular Acidosis and Hypophosphatemia Induced by Arginine.- Cardiac Function and Metabolism in Phosphorous Depleted Dogs — Effects of Hormonal Stimulation.- Circulatory Response to Pressor Agents in Phosphorous Depletion.- Phosphate and Vanadate Reduce the Efficiency of the Chemo-Mechanical Energy Transformation in Cardiac Muscle.- Effects of Hypophosphatemia on Pulmonary Muscle Performance.- Experimental Alcoholism Induces Phosphorus and Magnesium Deficiency in Skeletal Muscle.- Defective Hormonal Stimulation of Isolated Hepatocytes in Phosphorus Depleted Rats.- Should Hypophosphatemia Be Treated?.- IV. Topics on Vitamin V Metabolism.- Development and Application of an Exchange Assay for 1,25-Dihydroxy-Vitamin D3.- Effects of Systemic pH on Calcium Regulating Hormones and Bones.- Inherited and Acquired Disorders of Vitamin D Metabolism.- The Molecular Nature of 1,25-(OH)2-D3-Induced Calcium-Binding Protein Biosynthesis in the Rat.- Effects of 1,25-Dihydroxy Vitamin D3 in Patients with Early Renal Failure.- Increased serum 1,25-(OH)2-Vitamin D Concentrations Fail to Affect Serum or urine Phosphate in Humans.- Adrenergic Blackade May Inhibit the Increase in Plasma 1,25-(OH)2-Vitamin D During Phosphate Deprivation in the Rat.- V. Topics on Bone Metabolism.- Regulation of Osteoblast Activity and the Osteoblast-Osteocyte Transformation.- Role of Monocytes in Bone Resorption.- Coupling Factor.- Glutamine: A New Metabolic Substrate.- Evolution of Renal Osteodystrophy in Patients Treated by Continuous Ambulatory Peritoneal Dialysis.- VI. Calcium Metabolism.- Measurements of Intracellular Free Ca++.- The Regulation of Intracellular Calcium.- Calcium as Intracellular Messenger in Hormone Action.- Effects of Diuretics on Calcium Metabolism.- Effects of Chlorothiazide Administration and Dietary Calcium Restriction on Parathyroid Function, Vitamin D Metabolism and Intestinal Calcium Absorption in the Rat.- Calcium Fluxes Across Membranes Isolated from Small Intestinal Epithelium.- VII.Parathyroid Hormone Metabolism and Its Extraskeletal Effects.- The Parathyroid Hormone Molecule: Biological Implications of Structure.- Functional Properties of Parathyroid Hormone Receptors in Kidney and Bone.- Assessment of Biologically Active Parathyroid Hormone in Hyperparathyroid Man.- Effect of Parathyroid Hormone on Phospholipid Metabolism.- Effects of Parathyroid Hormone on Glomerular Ultrafiltration in the Rat.- Regulation Mechanisms of the Renal Phosphate Handling in Renal Failure — What is the Role of PTH?.- Interactions Between Liver and Parathyroid Hormone.- Parathyroid Hormone and the Heart.- Vascular Effects of Parathyroid Hormone (PTH).- Role of PTH, Metabolic Factors and Other Hormones in Extra-Renal Acid Buffering.- Effect of Parathyroid Hormone on the Isolated Papillary Muscle of the Rat Heart.- Effect of Parathyroid Hormone on Rat Enterocyte Na Transport in Vitro.- Comparison of Propranolol and Atenolol in the Control of Hyperparathyroidism in Uremia.- Effects of Oral Cimetidine on Parathyroid Hormone and Calcitonin Plasma Levels in Uremic Patients.