Regenerative Nephrology

ISBN-13: 9780128101964 / Angielski / Miękka / 2016 / 442 str.

Michael S. Goligorsky

Opis

Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts.

• Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers
• Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney

Recenzje

"The authors of Regenerative Nephrology have empowered a group of the leading investigators to provide a comprehensive overview of regenerative processes in the kidney. It spans the subject from cellular physiology to models and the first clinical trials of stem cell therapy. This book fills a gap in this rapidly expanding field. It will be an invaluable reference to the specialist investigator and a useful overview for those in nephrology or regenerative medicine who wish to become fully up to date with this important subject." --Christopher S. Wilcox, MD, PhD, George E. Schreiner Chair of Nephrology,Director, Center for Hypertension, Kidney and Vascular Health, Chief, Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC, USA

"Dr. Goligorsky has assembled an outstanding group of authors for his "Regenerative Nephrology" book. The publication of this authoritative work is timely. State-of-the-art knowledge about the phylogeny, ontogeny, and mediators of tissue regeneration is discussed and is critical in pursuing the potential role of stem cells in regenerative processes. The kidney is the organ responsible for total body homeostasis, therefore focusing on regeneration in acute and chronic kidney disease is very appropriate. Moreover, Goligorsky is an internationally prominent researcher in understanding the pathophysiology of kidney disease. Regenerative Nephrology has important sections dealing with the clinical aspects of stem cell therapy including potential risks and ethical issues. I highly recommend this important book, not just for scientists studying the kidney, but for all biomedical scientists, as the dawn of stem cell therapy in humans is emerging for many organs." --Robert W. Schrier, MD, Professor of Medicine, University of Colorado, School of Medicine, Denver, CO, USA

"With this book, Dr Goligorsky, along with his impressive collection of highly prominent authors, has certainly succeeded in achieving the goal of bringing an up-to-date review of the basic research of regenerative nephrology and its promising clinical applications to the attention of the interested reader. This is a truly international book; although the majority of the outstanding faculty is North American, excellent contributions have been written by Japanese, Australian and European authors.. This book is not only of interest to the basic expert investigator. Also, the interested teacher or clinician who wants to catch a glimpse of what will become possible in the near future in the treatment of a whole range of acute and chronic kidney diseases with these fascinating new tools will find this book a must.. Dr Goligorsky and his contributors have done a great service to most of us 'non-experts' by summarizing, in a brilliant manner, the recent advances in this field." --NDT Plus

Spis treści

PHYLOGENY AND ONTOGENY OF TISSUE REGENERATION 1. Glomerulogenesis and de novo nephrogenesis in medaka fish - evolutionary approach Yuko Wakamatsu and Hisashi Hashimoto 2. Renal Organogenesis: Growing a replacement kidney in situ from transplanted renal primordia Marc R. Hammerman 3. Use of Genetic Mouse Models to study Kidney Regeneration Akio Kobayashi and Jeremy S. Duffield

MEDIATORS OF REGENERATION 4. Endogenous Anti-Inflammatory and Pro-Resolving Lipid Mediators in Renal Disease Charles N. Serhan and Catherine Godson 5. Tissue protection and regeneration aided by erythropoietin and erythropoietin-derived peptides Danilo Fliser 6. Mast cells in kidney regeneration Eric Daugas, Walid Beghdadi and Ulrich Blank 7. Role of macrophages in renal injury, repair and regeneration Vincent Lee, Qi Cao, Yiping Wang and David C.H. Harris 8. T-cells contribution to regenerative processes Hamid Rabb

STEM CELLS IN REGENERATIVE PROCESSES 9. MSC and reparative processes Benjamin D. Humphreys and John V. Bonventre 10. Stem cells in regenerative processes: Endothelial progenitor cells and the kidney Matthieu Monge, Anton J. van Zonneveld and Ton J. Rabelink 11. The potential of the side population in regenerative nephrology Melissa H. Little and G. A. Challen 12. Very small embryonic like stem cells (VSELs) and their potential relevance for kidney homeostasis Dong-Myung Shin, Rui Liu, Janina Ratajczak, Magda Kucia and Mariusz Z. Ratajczak 13. Stem Cells in Regenerative Processes; Induced Pluripotent Stem Cells Kenji Osafune and Shinya Yamanaka 14. Methods of Isolation and Culture of Adult Stem cells Lindolfo da Silva Meirelles and Nance Beyer Nardi

STEM CELLS - FROM THE NICHE TO REPAIR 15. Stem cell niche in the kidney Laura Lasagni, Elena Lazzeri and Paola Romagnani 16. Creation of artificial niches Glenn D. Prestwich, Tammer Ghaly, Philip Brudnicki, Brian Ratliff and Michael S. Goligorsky 17. Imaging of transplanted and native stem cells Xiang-Yang Zhu, Martin Rodriguez-Porcel and Lilach O. Lerman

CAUSES OF REGENERATIVE FAILURE 16. Stem cell injury and premature senescence Michael S. Goligorsky 17. Regeneration and Aging: Regulation by Sirtuins and the NAD⁺ Salvage Pathway Nica M. Borradaile, Alanna Watson, and J. Geoffrey Pickering 18. Bone marrow-mesenchymal stem cells in organ repair and strategies to optimize their efficacy Christodoulos Xinaris, Barbara Imberti, Giuseppe Remuzzi and Marina Morigi

EMERGING CLINICAL ASPECTS OF STEM CELL THERAPY 19. Treatment of Acute Kidney Injury with allogeneic Mesenchymal Stem Cells: Preclinical and initial Clinical Data Florian E. Tögel and Christof Westenfelder 20. Clinical trials in Renal Regenerative Medicine Maarten B. Rookmaaker, Jaap A. Joles and Marianne C. Verhaar 21. Potential risks of stem cell therapies Uta Kunter and Jürgen Floege 22. Tissue engineering in urology Anthony Atala 23. Ethical issues in SC therapy Donald W. Landry 24. Stem Cell Banking Vicente Mirabet and Pilar Solves