Redox Proteins in Supercomplexes and Signalosomes

ISBN-13: 9781482251104 / Angielski / Twarda / 2015 / 364 str.

Ricardo O. Louro; Irene Diaz-Moreno

Opis

Get Insight on the Function of Supercomplexes in Biological Systems Redox Proteins in Supercomplexes and Signalosomes is one of the first books to explore the key role played by redox proteins and their interaction network in a wide range of essential cellular processes in all domains of life. The book explains how the mitochondrial respiratory chain is dynamically organized in supercomplexes even under physiological conditions. It also addresses the impact of supercomplex assembly on mitochondrial morphology, physiology, and biogenesis to shed light on the molecular mechanisms of pathological situations, including aging. Discover the Connection between Bioenergetic Supercomplexes and Signalosomes Compiling state-of-the-art research from leading practitioners in the field, this book gives you guidance on dealing with these biological systems in your investigations. The book shows that supercomplexes and signalosomes provide the link between reductive and systems biology, which enables us to understand how the molecular properties of individual macromolecular components trigger cellular function.

Recenzje

"This book covers perfectly the remarkable development and progress achieved in this multi-disciplinary field of modern biosciences. Thanks to the excellent selection of themes and well-recognized authors, it will be extremely useful for a broad scientific community. Clearly a book indispensable for both the expert as well as for the graduate student, bringing together the essential knowledge in a compact and up-to-date manner. The readers are introduced in a professional way to the exciting world of supercomplexes and signalosomes, which will enable them to grasp the state of the art and advancements in this rapidly developing research area."
—Peter M.H. Kroneck, Professor of Biochemistry, Department of Biology, University of Konstanz

Spis treści

Multi-Electron Transfer in Biological Systems. Diversity of Interactions in Redox Systems: From Short- to Long-Lived Complexes. ATPases and Mitochondrial Supercomplexes. Role of Cardiolipin in Mitochondrial Supercomplex Assembly. Mitochondrial Supercomplexes and ROS Regulation: Implications for Ageing. Mitochondrial Respiratory Supercomplexes in Physiology and Diseases. Regulation of Photosynthetic Electron Transport via Supercomplex Formation in the Thylakoid Membrane. Microbial Redox Proteins and Protein Complexes for Extracellular Respiration. Unravelling New Metabolic Pathways: Supramolecular Organisation of Aerobic Bacteria Respiratory Chains. Membrane Organisation and Electron Transport Switches in Cyanobacteria. Regulation of Cellular Signalling by Thioredoxin. Cytochrome c–Based Signalosome. Cell Membrane Raft Redox Signalosomes: Platform Responding to Danger Signals. Conclusions.