Recent Progress in Failing Heart Syndrome

ISBN-13: 9784431680192 / Angielski / Miękka / 2011 / 344 str.

Shigetake Sasayama;Hiroyuki Suga

Opis

Heart failure is a syndrome caused by a heart dysfunction that leads to insuf- ficient blood in the peripheral tissues for their metabolic demands. This syn- drome still remains an obscure clinical entity and even its definition is disputed. It has become increasingly apparent that heart failure may relate not only to cardiac dysfunction but also to other physiological alterations involved in the maintenance of circulatory homeostasis. In 1988, the Japanese Circulation Society organized a three-year project for research on heart failure. The research group consisted of ten investigators, all relatively young but well recognized internationally for their research accomplishments. This book represents a compilation of the achievements by this group during the past three years which have led to new insights into the pathophysiologic mechanisms of heart failure, and diagnosis, evaluation and treatment of this syndrome. Contents include research into the cellular biology of congestive heart failure, and a framework of pressure-volume relationships enabling assessment of ventricular contraction energetics or coupling of ventricular properties and arterial load. This conceptual framework is of vital significance, particularly when we consider the failing heart as an energy-depleted state. An understanding of the neuroendocrine responses to explain the pathophy- siology of congestive heart failure is perhaps the most important advance, and has led to new developments in therapy. This book also includes an analysis of mechanical factors, including both regional, and global ventricular functions, and this is related to the under- standing of the pathophysiology of congestive heart failure.

Spis treści

1 Reconstitution of Actin-Myosin Interaction In Vitro: Its Application to Cardiac Physiology.- 2 Molecular Basis for Cardiac Adaptation to Overload.- 3 Role of Ca2+ Overload in Myocardial Contractile Dysfunction.- 4 Cardiac Oxygen Costs of Contractility (Emax) and Mechanical Energy (PVA): New Key Concepts in Cardiac Energetics.- 5 Left Ventricular Regional Mechanics and Energetics Assessed in the Wall Tension-Regional Area Diagram.- 6 Myocardial Energetics of Hypertrophied Heart of Spontaneously Hypertensive Rat and Stroke-Prone Spontaneously Hypertensive Rat.- 7 Optimal Left Ventricle Versus Optimal Afterload.- 8 Coupling Between Ventricluar and Arterial Properties.- 9 Neurohumoral Mechanisms in Chronic Heart Failure.- 10 Effects of Rapid Pacing Stress on Ventricular Function of Hypertrophied Human Heart.- 11 Regional Work of the Left Ventricle and Contractility Index Independent of Ventricular Size.- 12 Selective Stimulation of High-Affinity ?1-Receptors: Its Implication in the Treatment of Mild Heart Failure.- 13 Hemodynamic and Histopathological Consideration of Left Ventricular Assist System on Acute Myocardial Infarction: Experimental and Clinical Investigation.- 14 Therapeutic Effects of the Left Ventricular Assist System on Myocardial Ischemia.