Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology

ISBN-13: 9783031123979 / Angielski / Twarda / 2022 / 381 str.

Seth Kwabena Amponsah; Yashwant V. Pathak

Opis

This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring.  
This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome.  The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies.

The book fills a gap in published literature and provides reliable information on;

 

1. Analytical techniques in TDM and clinical toxicology 
2. TDM and pharmacokinetic studies 
3. TDM of drugs with narrow therapeutic indices 
4. Artificial intelligence in TDM and clinical toxicology 
5. Future directions and challenges 

Spis treści

Chapter Titles

1 Therapeutic and toxic concentration of drugs in biological matrices

2 Analytical techniques for therapeutic drug monitoring and clinical toxicology

3 Plasma therapeutic drug monitoring and clinical toxicology

4 Dried blood spots in therapeutic drug monitoring and toxicology

5 The role of artificial intelligence in therapeutic drug monitoring and clinical toxicity

6 Therapeutic drug monitoring and optimal pharmacotherapy with medicines of narrow therapeutic index

7 Therapeutic drug monitoring (TDM) and toxicological studies in alternative biological matrices

8 Analyzing data from therapeutic drug monitoring, pharmacokinetics, and clinical toxicology studies

9 Reducing toxicity in critically ill patients by using therapeutic drug monitoring

10 Quality assurance of samples for therapeutic drug monitoring and clinical toxicology

11 Therapeutic drug monitoring and toxicology of anticancer drugs

12 Therapeutic drug monitoring and toxicology of immunosuppressant

13 Therapeutic drug monitoring and toxicology: relevance of measuring metabolites

14 Recent advances in nanosensors for Therapeutic Drug Monitoring (TDM)

15 Organ toxicity by immunosuppressive drugs in solid organ transplantation

16 Artificial intelligence-based techniques to assess drug toxicity in drug induced liver injury (DILI) disease

17 Drug dose and therapy individualization

18 Models for drug individualization: patient to population level

19 Toxicity evaluation of nanomedicine

20 Biochemical indices of drug toxicity

21 Therapeutic drug monitoring and clinical toxicology: challenges and future directions

O autorze

Seth Kwabena Amponsah (PhD) is a Senior Lecturer and Head of Department of Medical Pharmacology, University of Ghana Medical School. He has an MPhil and PhD in Pharmacology. He has over 10 years' experience in teaching and research. His research focus includes Clinical Pharmacology (infectious disease and antimicrobial stewardship): prudent use of antimicrobials, antimicrobial level monitoring, and efficacy of antimicrobials in patients. He also has experience in therapeutic drug monitoring, population pharmacokinetic modeling; non-compartment pharmacokinetic and pharmacodynamic estimation; and pharmacokinetic evaluation of new drug formulations. He has published over 40 research articles, 3 book chapters and several conference abstracts.

Dr. Yashwant Pathak has over 13 years of versatile administrative experience in an institution of higher education as Dean (and over 30 years as faculty and as a researcher in higher education after his Ph.D). He now holds the position for Associate Dean for Faculty Affairs and tenured professor of Pharmaceutical Sciences. Dr. Pathak is an internationally recognized scholar, researcher and educator in the areas of health care education, nanotechnology, drug delivery systems and nutraceuticals. He has published extensively with over 50 edited volumes in the area of nanotechnology, drug delivery systems, artificial neural networks, conflict management and cultural studies. He has over 300 research papers, reviews, and chapters in books and presented in many national and international conferences. He is also actively involved many nonprofit organizations, to mention a few, Hindu Swayamsevak Sangh (USA), Sewa International (USA), International accreditation council for Dharma Schools and colleges, International commission for Human rights and religious freedom.