Recent Advances in Stem Cells: From Basic Research to Clinical Applications

ISBN-13: 9783319814728 / Angielski / Miękka / 2018 / 269 str.

Essam M. Abdelalim

Spis treści

Preface.- 1. Patents and Ethics in Stem Cell Research.- 2. Stem Cells for Drug Screening.- 3. Genome Editing in Human Pluripotent Stem Cells.- 4. Pluripotent Stem Cells for Kidney Diseases.- 5. Pluripotent Stem Cells for Modeling Motor Neuron Diseases.- 6. Pluripotent Stem Cell-derived Pancreatic β Cells: From in vitro Maturation to Clinical Application.- 7. Clinical Applications of Induced Pluripotent Stem Cells in Cancer.- 8. Banking of Human Umbilical Cord Blood Stem Cells and Their Clinical Applications.- 9. Interactions Between Multipotential Stromal Cells (MSCs) and Immune Cells During Bone Healing.- 10. Adult Stem Cells for Bone Repair: Translational Aspects.- 11. Neural Crest Stem Cells: A Therapeutic Hope Machine for Neural Regeneration.- 12. Lung Stem Cells and Their Use for Patient Care: Are We There Yet?.- Index.

O autorze

Dr. Essam M. Abdelalim is a Scientist at Qatar Biomedical Research Institute (QBRI) in Doha, Qatar and an Assistant Professor at Hamad Bin Khalifa University (HBKU) in that city. He is also Associate Professor at the Suez Canal University in Ismailia, Egypt, where he received his B.Sc. degree and his M.Sc. degree. He received his Ph.D. in Medical Science from Shiga University of Medical Science in Otsu, Japan and was later appointed Assistant Professor at that university. Dr. Abdelalim was awarded a Postdoctoral Fellowship from the Japan Society for Promotion of Science, where he studied the roles of natriuretic peptides and p53 in the regulation of self-renewal, pluripotency, and differentiation of embryonic stem cells (ESCs).

Dr. Abdelalim’s research interests focus on understanding the molecular mechanisms controlling unique characteristics of pluripotent stem cells (PSCs) and establishing their differentiation into specific cell types. His current research focuses on the potential use of PSCs to study diabetes, insulin resistance, and pancreatic beta cell development.

Blurb

This volume explores recent advances in the use of pluripotent stem cells (PSCs) and adult stem cells (ASCs) in basic and clinical applications.  The chapters discuss use of PSCs for drug screening, genome editing, modeling of kidney, motor neuron diseases, and diabetes as well as their application in cancer;  ASCs are discussed in the contexts of banking of umbilical cord stem cells, use of multipotential stromal cells (MSCs) for bone repair, cellular interactions during fracture repair stages, and therapeutic applications of neural crest stem cells and lung stem cells. The text is organized by sections dealing with PSCs and ASCs specifically, presenting the reader with a comprehensive examination of both these forms of stem cells.

Expertly authored and drawing from a wealth of international perspectives, Recent Advances in Stem Cells: From Basic Research to Clinical  Applications presents a succinct yet detailed review of cutting-edge research in this rapidly expanding field. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is essential reading for academics, researchers, and clinicians in the fields of cell biology, genetics, nephrology, osteology, oncology, and pulmonology.