Recent Advances in Parkinsons Disease: Part II: Translational and Clinical Research Volume 184

ISBN-13: 9780444537508 / Angielski / Twarda / 2010 / 358 str.

Anders Bjorklund

Opis

This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles.

• Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications
• Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
• All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Spis treści

Section I: Animal models of PD

1. What have we learned from Drosophila Models of Parkinson's Disease? - Ming Guo
2. Neurotoxic in vivo models of Parkinson's disease: recent advances - Timothy Greenamyre & Jason R. Cannon
3. Behavioural analysis of motor and non-motor symptoms in rodent models of Parkinson's disease - Stephen B. Dunnett & Mariah Lelos
4. Genetic mouse models of Parkinson's disease: the state of the art - Marie-Francoise Chesselet & Iddo Magen
5. Viral vector mediated overexpression of a-synuclein as a progressive model of Parkinson's disease - Anders Bjorklund, Ayse Ulusoy, Mickael Decressac, Deniz Kirik
6. Modelling inflammatory pathogenesis of Parkinson's Disease - Malu Tansey & Christopher J. Barnum
7. The MPTP-lesioned non-human primate models of Parkinson's disease. Past, present and future - Susan Fox & Jonathan Brotchie

Section II: Exploring PD with brain imaging

8. Abnormal Metabolic Brain Networks in Parkinson's Disease: From Blackboard to Bedside - David Eidelberg & Chris C. Tang
9. Imaging the Nigrostriatal System to Monitor Disease Progression and Treatment-Induced Complications - Jon Stoessl & Renju Kuriakose
10. Brain imaging after neural transplantation - Paola Piccini & Marios Politis
11. Imaging non-motor aspects of Parkinson's disease - David Brooks & Nicola Pavese

Section III: Frontiers in PD treatment

12. Gene therapy for dopamine replacement - Deniz Kirik & Tomas Björklund, Erik Ahlm Cederfjäll
13. Neurotrophic Factor Therapy for Parkinson's disease - Jeffrey Kordower, Rangasamy Suresh Babu, Katherine Soderstrom, Roy A.E. Bakay
14. Neural grafting in Parkinson's disease: Problems and possibilities - Patrik Brundin, Roger A Barker and Malin Parmar
15. Neural grafting in Parkinson´s disease: Unraveling the mechanisms underlying graft-induced dyskinesia - Emma L Lane, Anders Björklund, Stephen B Dunnett, Christian Winkler
16. Deep Brain Stimulation: State of the Art and Novel Stimulation Targets - Andres Lozano & Francisco A. Ponce
17. The challenge of Non-Motor Symptoms in Parkinson´s Disease - Ray Chaudhuri & Per Odin

O autorze

As a neuroanatomist and developmental neurobiologist, during the 1970s Björklund's lab originated reliable methods for transplantation of embryonic tissues into brain that pioneered practical cell transplantation in the central nervous system, providing the basis for technologies that are now used by laboratories world-wide. In parallel, work in the field has progressed from basic anatomical and developmental studies in experimental animals, via applications for assessing cell replacement and repair using primary and stem cells in the damaged brain, and now underpinning the majority of methods in development for cell therapy in patients. His laboratory continues to analyse the fundamental neurobiology and principles of cell transplantation, regeneration and integration in the CNS, as well as originating the first trials of effective clinical cell transplantation (for Parkinson's disease) in patients Angela Cenci Nilsson (author name M. A. Cenci) is Professor of Experimental Medical Research at Lund University (Sweden) where she heads the Basal Ganglia Pathophysiology Group). The group's research activities address the pathophysiology and pharmacology of Parkinson's disease (PD) and L-DOPA-induced dyskinesia using a multidisciplinary and translational approach. Current projects span a large variety of topics, including synaptic dysfunctions, dopamine receptor signaling, gliovascular-neuronal interactions, and neurorestorative treatments to enhance function and plasticity in the damaged nigrostriatal pathway.

Angela has a combined clinical-basic science background, having graduated in Medicine and specialized in Neurology at the University of Verona (Italy) before obtaining a PhD degree in Neurobiology at Lund University under the supervision of Prof. Anders Björklund. In 2002 Angela received a tenured appointment as Associate Professor at Lund University, which was followed by an appointment as Full Professor in 2008.

Angela has pioneered the development of symptomatic models of parkinsonism and L-DOPA-induced dyskinesia in rodents, and exploited these models to discover cellular mechanisms of disease and new therapeutic approaches. For these research achievements, she has received several awards (such as, the Erik K. Fernström Award for Young Promising Investigators, the Medal of Honours for Parkinson´s Research by the Swedish Parkinson's Disease Foundation, and a recent membership in the Royal Academy for the Natural Sciences, Medicine and Technology in Lund). Angela currently serves on the scientific advisory boards and steering committees of several national and international research organizations, including the Swedish National Microscopy Infrastructure, The Swedish Parkinson's Research Foundation, the Swedish Brain Foundation, the International Association for Parkinsonism and Related Disorders (IAPDR), and the International Basal Ganglia Society (IBAGS).