Recent Advances in Immunology

ISBN-13: 9781468446517 / Angielski / Miękka / 2012 / 244 str.

Asuman U. Muftuoglu; Asuman U. Muftuoglu

Opis

The aim of this publication is to present the up-to-date views of the many eminent immunologists who contributed to the scientific program of the 5th European Immunology Meeting held in Istanbul in June 1982. Recent Advances in Immunology is intended for immunol ogists both in the basic sciences and in clinical medicine. It provides under one cover an assemblage of information about funda mental problems in immunology and clinical applications. The book opens with Prof. E. A. Kabat's review of the problems in understanding the structural basis of antibody complementarity. The succeeding four papers deal with the role of macrophages in the various stages of immune phenomena. The first of the two articles on T cells reports a product necessary for suppressor activity and the second describes an analysis of precursors of cytotoxic T lym phocytes. The articles dealing with immunogenetics start with the description of new loci in HLA by Prof. J. J. van Rood and co-workers followed by a paper describing the molecular cloning of H-2 class I genes. Prof. P. J. Lachmann begins the discussion on the genetics of the complement system. There are three stimulating articles on the chemistry and genetics of the complement components and their asso ciations with disease. After a review of artificial antigens and synthetic vaccines, papers on immunomodulation describe strategies for improving immunogenicity, immunomodulation in tumor systems and by xenobiotics."

Spis treści

Problems in Understanding the Generation of Antibody Complementarity.- Natural Immunity and Macrophages — Introductory Remarks.- Role of Macrophages in T Cell Activation.- Antigen Presentation by Dendritic Cells.- The Macrophage as a Cytotoxic Effector Cell in Mice and Humans.- A Cell-Free Product Secreted by Ly?2+ Cells Can Induce a Molecule Required for Ly2 Suppressor Cell Activity.- Frequency-Analysis of Precursors of Cytotoxic T Lymphocytes in Radiation Chimeras: Enumeration of Antigenspecific CTL-P Restricted to Thymic MHC- and Bone Marrow-MHC-Determinants.- New Loci in HLA.- Molecular Cloning of H-2 Class I Genes in the H-2b Haplotype.- Why Study Complement Genetics?.- The Family of Proteins Having Internal Thiolester Bonds.- Structural Analysis of Cloned Mouse and Human DNA Sequences Specifying C3, the Third Component of Complement.- HLA Encoded Genes and Their Associations with Disease.- Artificial Antigens and Synthetic Vaccines — A Review.- Strategies for Improving Immunogenicity: The Deliberate Association of MHC (HLA) Antigens with Other Molecules.- Immunomodulation in Tumor Systems.- Immunomodulation by Xenobiotics: Introductory Remarks to Immunotoxicology.- Antibody Producing Human-Human Hybridomas.- Lymphocyte Dysfunctions Associated with Enzyme Defects.- Immunologically Distinct Forms of Primary Hypogammaglobulinaemia: Studies Using Pokeweed Mitogen and Epstein-Barr Virus.- T Cell Subset Responses in Varied Immunodeficiency Syndromes.- Immune Dysfunctions in Ataxia-Telangiectasia.- Some Aspects of T Cell Regulation in Autoimmune Diseases.- Early Detection of Autoimmune Endocrine Disorders.- Permanent Lines of T Lymphocytes Specific for Acetylcholine Receptors: A Clonal Approach to Study the Pathogenesis of Myasthenia Gravis.- Human IgG Short-Term Sensitizing Anaphylactic Antibody: Differences in Properties from Those of IgG4.- Leukotrienes and Lipid Factors: Mediators and Modulators of the Inflammatory Reactions.- Calmodulin and Human Inflammatory Reactions.- Contributors.