Recent Advances in Epilepsy Research

ISBN-13: 9780306478604 / Angielski / Twarda / 2004 / 248 str.

Devin K. Binder; Helen E. Scharfman; Devin K. Binder

Opis

Epilepsy research has entered an exciting phase as advances in molecular analysis have supplemented in vitro and in vivo electrophysiologic and phenotypic characterization. Recent Advances in Epilepsy Research sets forth a series of chapter reviews by researchers involved in these advances. This volume is a composite profile of some exciting recent investigations in select areas of enquiry.
Key features: neurogenetics of seizure disorders, new developments in cellular and molecular neurobiology of seizure disorders, the role of growth factors in seizures, new advances in the roles of metabotropic glutamate receptors and GABA receptors and transporters, gap junctions, neuroimmunology of epilepsy, malformations of cortical development, neurogenesis, new animal models of epilepsy and the use of brain stimulation to treat epilepsy. This book should be of interest to a wide variety of audiences, including graduate students in neurobiology and related disciplines, neuroscientists, medical students, neurologists, neurosurgeons, and industry including pharmaceutical companies and medical device companies. There are many ideas in this book that will lead ingenious innovators in academia and industry to develop new and better therapies.

Spis treści

1. Genetic Approaches to Studying Mouse Models of Human Seizure Disorders.- 2. Integrins, Synaptic Plasticity and Epileptogenesis.- 3. The Role of Bdnf in Epilepsy and Other Diseases of the Mature Nervous System.- 4. Vascular Endothelial Growth Factor (Vegf) in Seizures: A Double-Edged Sword.- 5. Plasticity Mechanisms Underlying mGlur-Induced Epileptogenesis.- 6. Role of the Gaba Transporter in Epilepsy.- 7. Gaba and Its Receptors in Epilepsy.- 8. Role of the Depolarizing Gaba Response in Epilepsy.- 9. Gap Junctions, Fast Oscillations and the Initiation of Seizures.- 10. Functional Role of Proinflammatory and Anti-Inflammatory Cytokines in Seizures.- 11. Using the Immune System to Target Epilepsy.- 12. Cortical Dysplasiaand Epilepsy: Animal Models.- 13. Malformations of Cortical Development: Molecular Pathogenesis and Experimental Strategies.- 14. Functional Implications of Seizure-Induced Neurogenesis.- 15. Febrile Seizures and Mechanisms of Epileptogenesis: Insights From an Animal Model.- 16. The Tetanus Toxin Model of Chronic Epilepsy.- 17. Brain Stimulation as a Therapy for Epilepsy.