Recent Advances in Drug Delivery Systems

ISBN-13: 9781461297000 / Angielski / Miękka / 2011 / 404 str.

James M. Anderson; Sung Wan Kim; James M. Anderson

Opis

The evident rapid expansion of scientific work and intense interest in both experimental and clinical aspects of new drug delivery systems provided strong motivation for planning this symposium. In designing the program, speakers were identified for their particular expertise in a wide range of topics such as dermal delivery systems, pro-drugs, oral prolonged release, rate-controlled drug delivery, the pharmacokinetics of drug release systems, the synthesis of polymeric drug carriers and the refinement of drug delivery pumps. Because of the considerable involvement of diverse scientists from laboratories around the world where investigations relevant to the topic are now being pursued, a deliberate effort was made to invite international leaders in the field to share their knowledge and experimental outcomes. Thus, plenary papers and panel discussions were offered by organic chemists, bioengineers, patholo gists, material scientists, physical chemists, and pharmacokineti cists from academic and industrial laboratories in some dozen countries. This book which records the presentations offered at the sym posium covers a broad array of topics ranging from general overviews of the physicochemical concepts and analytical methodology which underpin the refinement of drug delivery systems and the tissue responses associated with the use of such systems through detailed discussions of a variety of current approaches employed in the development of new systems.

Spis treści

Topical Delivery of Antiviral Agents: InVivo/InVitro Correlations.- Biological Evaluation of Soluble Synthetic Polymers as Drug Carriers.- Tissue Responses to Drug Delivery Systems.- Synthesis of Tailor-Made Soluble Polymeric Drug Carriers.- New Oligomers and Polymers as Drug Carriers.- Synthesis, Characterization and Antitumor Activity of Macromolecular Prodrugs of Adriamycin.- Zero Order Drug Release from Bioerodible Polymers.- Self Regulating Insulin Delivery System — A Chemical Approach.- Antithrombotic Agent Releasing Polymers.- Polymer Coated Liposomes for Drug Delivery to Target Specific Organs.- Alternative Approaches to Oral Controlled Drug Delivery: Bioadhesives and In-Situ Systems.- Development of Encapsulated Antibiotics for Topical Administration to Wounds.- Albumin Microspheres for Intraarterial Drug Targeting.- A Bioresponsive Membrane for Insulin Delivery.- Magnetic Microspheres in Drug Delivery.- Drug Release from Matrix Devices.- Controlled Release and Magnetically Modulated Systems for Macromolecules: Recent Advances.- Hydrogel Drug Delivery Systems Physical and Ionogenic Drug Carriers.- Release of Bioactive Agents from Swellable Polymers: Theory and Experiments.- Polymeric Pseudolatex Dispersions as a New Topical Drug Delivery System.- Transdermal Drug Delivery from a Solid State Hydrophilic Reservoir System.- Sintered Polymers for Sustained Macromolecular Drug Release.- Noninvasive Monitoring of the In Vivo Release Characteristics of Rectal Drug Delivery Devices.- Technical Considerations for Advanced Drug Delivery Systems.- Insulin Delivery at Variable Rates from a Controlled Release Micropump.- Microsealed Drug Delivery Systems: Theoretical Aspects and Biomedical Assessments.- Contributors.