Recent Advances and Future Directions in Bone Marrow Transplantation: Proceedings of a Symposium Held in Conjunction with the 16th Annual Meeting of t

ISBN-13: 9781461283393 / Angielski / Miękka / 2011 / 200 str.

Sigmund J. Baum; George W. Santos; Fumimaro Takaku

Opis

This volume demonstrates the great progress made since the first successful allogeneic marrow transplants were performed in man over twenty years ago and also confronts today's unresolved significant problems. These include acute and chronic graft-versus-host disease, infection after bone marrow transplantation, and leukemic relapses. Discussion of experimental bone marrow transplantation focuses on such topics as the following: failure of self/nonself discrimination, prevention of transfusion-induced sensitization in marrow transplant recipients, bone marrow purging with chemical and photodynamic agents, autologous and allogeneic marrow transplants in leukemia and lymphoma, allogeneic and syngeneic marrow transplantation for aplastic anemia, marrow transplantation in patients with thalassemia and lysosomal storage diseases, and medical management of Chernobyl-type nuclear accidents.

Spis treści

I. Experimental Bone Marrow Transplantation.- 1 Graft-versus-Host Disease and Graft-versus-Leukemia in Experimental Systems.- 2 Syngeneic Graft-versus-Host Disease: Failure of Self: Non-Self Discrimination.- 3 Transfusion-Induced Allosensitization in Marrow Transplant Recipients: Mechanisms and Preventive Measures.- II. Experimental Bone Marrow Transplantation.- 4 Utilization of Monoclonal Antibodies for Autologous Bone Marrow Transplantation.- 5 Characterization of Malignant Lymphoma in Dogs and Use as a Model for the Development of Treatment Strategies.- 6 Hematopoietic Cell Transplantation in Murine Globoid Cell Leukodystrophy (The Twitcher Mouse)—A Model of a Human Sphingolipidosis (Krabbe Disease).- 7 Experimental Basis of Bone Marrow Purging with Chemical and Photodynamic Agents.- III. Leukemia.- 8 Oncogenes in Acute Myelogenous Leukemia.- 9 Optimal Timing of Marrow Transplantation for Patients with Acute Nonlymphoblastic and Acute Lymphoblastic Leukemia.- 10 Perspectives in Treatment of Adult Leukemia with High Dose Cytoreductive Therapy and Autologous Bone Marrow Treated Ex Vivo.- IV. Autologous and Allogeneic Marrow Transplants in Leukemia and Lymphoma (Session A).- 11 Allogeneic and Autologous Marrow Transplants in Acute Nonlymphoblastic Leukemia (ANLL).- 12 Allogeneic Transplantation for Acute Lymphoblastic Leukemia.- 13 Autologous Bone Marrow Transplantation in Acute Lymphoblastic Leukemia—Mafosfamide Italian Study Group.- 14 Allogeneic Bone Marrow Transplantation for Chronic Myeloid Leukemia.- V. Autologous and Allogeneic Marrow Transplants in Leukemia and Lymphoma (Session B).- 15 Autologous Marrow Transplantation for Hodgkin’s and Non-Hodgkin’s Lymphoma: Preliminary Results Using New Conditioning Regimens.- 16 Long-Term Bone Marrow Culture in Autologous Transplantation: An In Vitro Biological System for Purging Leukemic Cells.- 17 Allogeneic Bone Marrow Transplantation for Leukemia—Japanese Experience.- VI. Aplastic Anemia.- 18 Allogeneic and Syngeneic Marrow Transplantation for Aplastic Anemia: Overview of Seattle Results.- 19 Recent Advances and Future Trends in Bone Marrow Transplantation for Severe Aplastic Anemia.- 20 Allogeneic Bone Marrow Transplantation in Leukemia.- VII. Acute Graft-versus-Host Disease.- 21 Bone Marrow Transplantation: The Difficulties Ahead.- 22 Predictive Models of Graft-versus-Host Disease.- 23 Prevention of Severe GVHD Employing Cyclosporine in HLA-Matched Marrow Transplant for Leukemia.- VIII. Chronic Graft-versus-Host Disease.- 24 Chronic Graft-versus-Host Disease: Pathogenesis, Diagnosis, Treatment and Prognostic Factors.- 25 The Role of Autoreactive T Lymphocytes in Graft-versus-Host Disease (GVHD).- 26 Predictive Factors for Chronic Graft-versus-Host Disease and Leukemic Relapse After Allogeneic Bone Marrow Transplantation.- IX. Infections After Bone Marrow Transplants.- 27 Viral Infection Following Bone Marrow Transplantation.- 28 Bacterial, Fungal, and Protozoan Infection After Marrow Transplantation.- 29 Prevention and Treatment of Infections after Bone Marrow Transplantation.- X. Metabolic and Genetic Disorders.- 30 Bone Marrow Transplantation for Thalassemia: 156 Cases Transplanted in Pesaro.- 31 Improvement of Clinical Expression of Central Nervous System Manifestation in Lysosomal Storage Diseases Treated By Bone Marrow Transplantation.- 32 Bone Marrow Transplantation Following Nuclear Accidents.- Conclusions.