Reaction Mechanisms in Organic Chemistry

ISBN-13: 9783527349647 / Angielski / Twarda / 2021 / 640 str.

Metin Balci

Spis treści

BASIC CONCEPTSCovalent Bonding and HybridizationElectrophiles and NucleophilesInductive and Mesomeric EffectsFormal Charge And Oxidation NumberAcids And BasesReaction Kinetics And Energy DiagramsNUCLEOPHILIC SUBSTITUTION REACTIONSUnimolecular Substitution Reactions SN1Stereochemistry in SN1 ReactionsOptical ActivityBimolecular Substitution Reactions SN2Stereochemistry of SN2 ReactionsNucleophilic Substitution On Allylic Systems: Allylic RearrangementInternal Nucleophilic Substitution Reaction SNiNeighboring Group Participation in Nucleophilic Substitution ReactionsAmbident NucleophilesVarious Nucleophilic Substitution ReactionsELIMINATION REACTIONSUnimolecular Elimination Reactions, E1Bimolecular Elimination Reactions, E2Unimolecular Conjugate BaseHalogene EliminationHofmann Elimination: Quaternary Ammonium SaltsPyrolitic Eliminations: Intramolecular cis-Elimination ReactionsElimination at the Bridgehead: Bredt?s RuleADDITION REACTIONSHalogen Addition To Double Bonds: HalogenationAddition of Hydrogen Halides to Double Bonds: Markovnikov?s RuleAnti-Markovnikov Addition of Hydrogen Halides to AlkenesAddition of Water to AlkenesOxymercuration and DemercurationHydroboration of Alkenes: Anti-Markovnikov HydrationEpoxidation of the AlkenesVicinal cis-DihydroxylationDihydroxylation via PIFAEnzymatic DihydroxylationOzonolysis: Oxidative Cleavage of AlkenesReduction of AlkenesAddition to Conjugated DienesCARBONYL COMPOUNDS AND THEIR REACTIONSStructure-Reactivity RelationshipsReactions of Carbonyl CompoundsCarbonyl Addition ReactionsUmpolung: Polarity Inversion of Aldehyde Carbonyl GroupReactions of Aldehydes and Ketones with AminesReduction of Carbonyl GroupsReaction of Carbonyl Groups with Organometallic CompoundsReaction of Carbonyl Groups with YlidesPhosphonium Ylides and Wittig ReactionReactivity of alpha-Carbon AtomKeto-Enol TautomerismProton-Deuterium Exchangealpha-Halogenation of Ketones and Aldehydes: Haloform ReactionHell-Volhard-Zelinsky Reactionalpha-Alkylation of Carbonyl CompoundsEnolates Derived from 1,3-Dicarbonyl CompoundsCondensation Reactions of Carbonyl CompoundsTypical Reactions of Acids and EstersTransesterificationAROMATIC COMPOUNDSStructure of BenzeneAromatic, Antiaromatic, and Nonaromatic CompoundsDetermination of the Molecular orbitals of Aromatic CompoundsWhat are the criteria for aromaticity? How does one quantify aromaticity?HomoaromaticityMöbius AromaticityAromatic IonsAnnulenesAromaticity in Fused SystemsAromaticity in Heterocyclic CompoundsElectrophilic Aromatic Substitution: Chemistry of BenzeneReactivity of Monosubstituted Benzene DerivativesDirecting Effects of Substituents: Activating GroupsElectrophilic Aromatic Substitution on Disubstituted BenzenesFunctionalization of the Side Chain Substituents of BenzeneNucleophilic Aromatic Substitution ReactionsPolycyclic Aromatic CompoundsBenzenoid Aromatic CompoundsREACTIVE INTERMEDIATESCarbocationsCarbanionsCarbenesNitrenesRadicalsSinglet OxygenPERICYCLIC REACTIONSWoodward Hoffmann RulesFrontier OrbitalsElectrocyclic ReactionsApplication of Woodward Hoffmann RulesCorrelation DiagramsCycloaddition ReactionsSecondary Orbital InteractionOrbital CoefficientsSigmatropic ReactionsCope and Claisen RearrangementCARBON-CARBON (C-C) COUPLING REACTIONSHistoryMizoroki-Heck Coupling ReactionStille-Coupling ReactionSuzuki-Miyaura Coupling ReactionNegishi-Coupling ReactionSonogashira-Coupling ReactionKumada-Coupling ReactionHiyama-Coupling ReactionHiyama-Denmark CouplingBuchwald-Hartwig CouplingTsuji-Trost CouplingPalladium-catalyzed Carbonylation ReactionsCarbonylative Coupling Reactions with Organometallic ReagentsMo(CO)6-Mediated Carbonylation

O autorze

Metin Balci is Professor Emeritus of the Middle East Technical University in Ankara. He received his Ph.D. degree in 1976 from the University of Cologne, where he worked with Professor Emanuel Vogel. He did post-doctoral work with Professors Harald Günther (Siegen, Germany), Waldemar Adam (Puerto Rico) and W. M. Jones (Florida). In 1980 he joined the Department of Chemistry at the Atatürk University and he has been a full professor there since 1987. In 1997 he moved to the Middle East Technical University in Ankara upon reputation. Metin Balci has received several prices: In 1983 "Junior Research Prize" and "Scientific Prize" in 1989 from the Scientific and Technical Research Council of Turkey and the Best Teacher Award in 2000, 2003, 2004 at the Middle East Technical University (METU). Furthermore, he received METU "Academic Achievement Award", (2000-2015). His main research interest include synthesis of cyclitols, endoperoxides, cyclic strained compounds, bromine chemistry, and heterocyclic compounds. He has published 280 scientific papers and he retired in 2015.