Radionuclide Therapy

ISBN-13: 9783030972196 / Angielski / Twarda / 2022

Opis

The main purpose of this book is to create a reference for the indications, contraindications, patient selection, treatment practice, treatment side effect management, and follow-up of radionuclide treatments.

Besides standard methods such as surgery, chemotherapy, radiotherapy, and hormone therapy, newly developed biological treatments, targeted treatments, personalized treatments, external beam radiotherapy, and targeted radionuclide treatments have begun to take their place in professional practice. Nuclear medicine, in addition to its role as a tracer of cancer, also assumes the role of treating with radioactive molecules directed to the cancer it traces. These traceable next-generation radionuclide treatments, whose efficacy and reliability have been proven and where diagnosis, treatment, and follow-up are carried out together, are increasingly included in oncology practice together with the new developed radiopharmaceuticals, ensuring a high rate of damage to cancer cells while protecting the surrounding normal tissues. Molecular cancer treatment will become more effective with individualized next-generation traceable radionuclide treatments, which will be shaped by genetic studies in the future.Radionuclide treatments for many cancer types and benign diseases are presented by experienced nuclear medicine experts in the light of their own experience and case studies, while systemic treatments in common cancer types and side effect management of these treatments are summarized by medical oncologists.  This book will be of interest to nuclear medicine physicians as well as oncologists.

Spis treści

Part-1: Basic Information 

1. Basic properties and preparation of radiopharmaceuticals used in radionuclide therapy

2. Physical Bases of Radionuclide Therapy (Biological Effects and Properties of Particle Radiation)

3. Fundamentals of radiation safety and dosimetric approach in radionuclide therapy applications

Part-2: Clinical Information: Thyroid Diseases

4. Radionuclide Therapy in Benign Thyroid Diseases: Nodular Goiter Disease

5. Radionuclide Therapy in Benign Thyroid Diseases: Graves' Disease 

6. Radionuclide Therapy in Malignant Thyroid Diseases: Differentiated Thyroid Cancer

7. Radionuclide Therapy in Malignant Thyroid Diseases: Medullary Thyroid Cancer 

8. Systemic Treatments and related side effects in Thyroid Cancer 

Part-2: Clinical Information: Neuroendocrine Tumors

9. Radionuclide Therapy in Neuroendocrine Tumors

10. Systemic Treatments and related side effects in Neuroendocrine Tumors

 Part-4: Clinical Information: Neuroectodermal Tumors

11. Radionuclide Therapy in Neuroectodermal Tumors

12. Systemic Treatments and  related side effects in Neuroectodermal Tumors 

Part-5: Clinical Information: Liver Tumors

13. Radionuclide Therapy in Liver Tumors

14. Systemic Treatments and  related side effects in Liver Tumors

Part-6: Clinical Information:  Prostate Cancer

15. Radionuclide Therapy in Prostate Cancer

16. Systemic Treatments and related side effects in Prostate Cancer

17. Radionuclide Therapy in Joint Diseases: Radiosynovectomy

18. Radionuclide Pain Palliation Therapy

Part-7: Clinical Information:  Bone and Joint Diseases

19. Radionuclide Therapy with Alpha Emitting Agents in Bone Metastases 

Part-8: Clinical Information: Lymphoproliferative Diseases 

20. Radionuclide Therapy in Lymphoproliferative Diseases

Part-9: Radioimmunotherapy 

21. Basics and clinical applications of radioimmunotherapy

Part-10: Intracavitary Radionuclide Therapy

22. Intracavitary radionuclide applications

O autorze

Prof. Dr. Recep Bekiş graduated from Sivas High School in 1985. Between 1985-1991, he studied Medicine at Cumhuriyet University Faculty of Medicine. He graduated from the Faculty of Medicine in 1991 and worked as a general practitioner at Ankara Oncology Hospital between 1991-1996. He attended courses and seminars in the field of oncology. In 1996, he started as an assistant in Nuclear Medicine at Dokuz Eylul University Faculty of Medicine. He became a nuclear medicine specialist in 2000, assistant professor in 2002, associate professor in 2006, and professor in 2011. He is currently working as a faculty member at Dokuz Eylül University Faculty of Medicine, Department of Nuclear Medicine. He was appointed as the head of Nuclear Medicine Department at Dokuz Eylul University Faculty of Medicine, and as an assistant chief physician.

He published 71 articles in national and international journals and 157 notifications in national and international scientific meetings. He is a chapter author in a book and chief editor in a book. He teaches at the medical faculty and health vocational high school. He is a member of professional scientific organizations and works actively in working groups in these organizations.

Prof. Dr. Berna Polack, a nuclear medicine specialist by training, has been working in molecular imaging and radioligand therapies since 1991. She became a nuclear medicine professor in 2005 at Dokuz Eylul University, Izmir, Turkey.  Dr. Polack has a European Nuclear Medicine Fellowship Board.

During her carrier, she also worked as research professor and visiting professor positions at the Pittsburg University of Medical Center (July 2003- October 2004), Cornell University Weil Medical College Radiology Department (July 2013-December 2014), and Columbia University Medical Center Radiology Department (September 2016- May 2017). During her positions, she presented lectures in radiology residency training programs and attended research studies as well as imaging evaluation and multidisciplinary oncology tumor boards.

She is the first or co-author of multiple publications published in SCI and SCI-expanded medical journals and two international nuclear medicine textbook chapters. She is the editor of a book entitled “PET/CT in Oncology”. Dr. Polack presented numerous congress presentations in national and international congresses. Additionally, she was awarded multiple national and international nuclear medicine research awards. She served as a director of the Turkish Nuclear Medicine Association Oncology Task Group.

After she retired from Dokuz Eylul University in 2017, Dr. Polack joined the pharmaceutical industry, focusing on innovative molecular imaging and radioligand therapies. She is currently working as Medical Director, Prostate Cancer RLT at Novartis.

Her main areas of focus are nuclear oncology, innovative molecular imaging, and radioligand therapies.

 

 

Prof. Dr Murat Fani Bozkurt completed his medical training at Hacettepe University Medical School in 1997. He had his residency training at Department of Nuclear Medicine, Hacettepe University from 1997 to 2003. Dr Bozkurt completed a reseach fellowship program on oncological PET imaging at University of Pennsylvania PET Center in Philadelphia, USA in 2003. He began to work as a staff at Department of Nuclear Medicine, Hacettepe University Faculty of Medicine in 2005.

Dr Bozkurt completed a visiting scientist program on Cardiac PET imaging at Nuclear Cardiology Department at Harvard University Brigham and Women’s Hospital in 2009.

Dr Bozkurt had his associate professorship degree in 2010. He was also certified by European Board of Nuclear Medicine in the same year.

He was assigned as a member of Oncology Task Group of European Association of Nuclear Medicine (EANM) in 2010 and consequently functioned as senior advisor in the years 2014-2016. He undertook chief chair position for European Multimodality Imaging and Therapy (ESMIT) in the years 2016-2018.

He had his professorship degree in Nuclear Medicine in the year 2019. Dr Bozkurt has been a member of executive board of Turkish Society of Nuclear Medicine since 2014 and editor of Molecular Imaging and Radionuclide Therapy (MIRT) since 2021.

Dr Bozkurt was rewarded by Turkish Cancer Research Council in 2003, for the best presentation at IX. National Gynecologic Oncology Congress in the year 2004 and for the best international presentation awards in the years 2016 and 2017 at American Association of Nuclear Medicine Physicains (ACNM). He represented Turkey at the first Young Investigator’s Meeting in the field of nuclear medicine therapy by EANM.

His areas of main interest are nuclear oncology diagnostic and therapeutic applications (especially Y-90 microsphere therapy for liver tumors), nuclear cardiology and intraoperative gamma probe applications.